Results 71 to 80 of about 7,742,545 (234)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles

, 2022
Late follicular phase progesterone elevation during in vitro fertilization impedes embryo implantation. It is unclear whether late follicular phase progesterone elevation still has a negative effect on cumulative live births and embryo quality when a ...
Canquan Zhou, Wu, Rihan, Hu, Xiaokun, Yangxing Wen, Xiaokun Hu, Huang, Ling, Ling Huang, Zhang, Xiubing, Huang, Sunxing, Xiubing Zhang, Rihan Wu, Zhou, Canquan, Minghui Chen, Wen, Yangxing, Chen, Minghui, Sunxing Huang   +15 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Anti-Müllerian hormone is correlated with cumulative live birth in minimal ovarian stimulation with clomiphene citrate: a retrospective cohort study

BMC Pregnancy and Childbirth, 2020
Background Several studies have investigated the correlation between the serum anti-Müllerian hormone (AMH) level and in vitro fertilization (IVF) outcomes in controlled ovarian stimulation cycles; however, studies regarding the correlation of the serum ...
Kenji Ezoe, Xiaowen Ni, Tamotsu Kobayashi, Keiichi Kato   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective cohort study

Frontiers in Endocrinology
BackgroundHyperthyroidism adversely impacts female reproduction, yet its association with in vitro fertilization (IVF) outcomes remains controversial. It remains unknown whether ovarian function recovers upon achieving euthyroidism.
Huizi Jin, Jiejun Luo, Menglu Wu, Yuxuan Fang, Zijin Xu, Lin Zhu, Mingzhu Cao, Zhu Liang, Jing Wang, Yanshan Lin, Yixuan Wu, Wenju Peng, Wenju Peng, Haiying Liu, Jian-Qiao Liu   +14 more
doaj   +1 more source

Cumulative live birth rates following a ‘freeze-all’ strategy: a population-based study [PDF]

Human Reproduction Open, 2019
What is the cumulative live birth rate following a 'freeze-all' strategy compared with a 'fresh-transfer' strategy?The 'freeze-all' strategy resulted in a similar cumulative live birth rate as the 'fresh-transfer' strategy among high responders (>15 oocytes retrieved) but did not benefit normal (10-15 oocytes) and suboptimal responders (15 oocytes ...
Z Li, A Y Wang, M Bowman, K Hammarberg, C Farquhar, L Johnson, N Safi, E A Sullivan   +7 more
openaire   +2 more sources

Attachment of a trophoblastic spheroid onto endometrial epithelial cells predicts cumulative live birth in women aged 35 and older

, 2023
ObjectiveTo evaluate the attachment rate of a human embryonic stem cell–derived trophoblastic spheroid onto endometrial epithelial cells in predicting the cumulative live birth rate of an in vitro fertilization (IVF) cycle.DesignA prospective ...
Ernest Hung Yu Ng, Andy Chun Hang Chen, Mei Ting Lam, Lam, Mei Ting, Yin Lau Lee, Raymond Hang Wun Li, Fong, Sze Wan, Chen, Andy Chun Hang, Ruan, Hanzhang, Lee, Kai Chuen, Lee, Kai Fai, Yue, Chaomin, Ng, Ernest Hung Yu, Kai Fai Lee, William Shu Biu Yeung, Li, Raymond Hang Wun, Lee, Yin Lau, Yeung, William Shu Biu, Kai Chuen Lee, Sze Wan Fong, Chaomin Yue, Hanzhang Ruan   +21 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source