Results 81 to 90 of about 8,217,055 (263)

Analysis of cumulative outcomes and influencing factors of patients with discrepancies between age and AMH levels in the early follicular phase prolonged protocol

Frontiers in Endocrinology, 2023
ObjectiveTo explore the cumulative outcomes and influencing factors of patients with discrepancies between age and Anti-Müllerian hormone (AMH) levels in the early follicular phase prolonged protocol.MethodsA total of 1282 cycles of in-vitro ...
Kexin Wang, Yichun Guan, Yuchao Zhang, Ruolin Jia, Shanshan Wu, Zhuolin Yao, Mingmei Zhang, Zhen Li   +7 more
doaj   +1 more source

Higher Cumulative Live Birth Rate but Also Higher Late Miscarriage Risk in Non-Obese Women with Polycystic Ovary Syndrome Undergoing the First IVF/ICSI Cycle

International Journal of Women's Health
Purpose To determine the impact of polycystic ovary syndrome on in vitro fertilization/intracytoplasmic sperm injection and embryo transfer outcomes while analyzing the influencing factors. Patients and Methods A retrospective cohort study comprised 4839
Simin Liu, Xiu Zhou, H. Jie, Ze-Tong Zheng, B. Cai, Qing-Yun Mai, Can-Quan Zhou   +6 more
semanticscholar   +1 more source

Dyslipidemia Is Negatively Associated With the Cumulative Live-Birth Rate in Patients Without PCOS Following IVF/ICSI

Frontiers in Physiology, 2021
Objective: To evaluate the effect of dyslipidemia on the cumulative live-birth rate (cLBR) in patients without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection–embryo transfer (IVF/ICSI–ET) cycles ...
Zhenteng Liu, Jian-Xiang Cong, Xue-Mei Liu, Hui-Shan Zhao, Shou-Cui Lai, Shunzhi He, H. Bao   +6 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

AMH Highly Correlates with Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age.

Journal of Clinical Endocrinology and Metabolism, 2021
CONTEXT Antimullerian hormone (AMH) level is strongly associated with ovarian response in reproductive technology (ART) cycles but is a poor predictor of live birth. It is unknown whether AMH is associated with cumulative live birth rates (CLBR) in women
R. Tal, D. Seifer, Renana Tal, E. Granger, E. Wantman, Oded Tal   +5 more
semanticscholar   +1 more source

Attachment of a trophoblastic spheroid onto endometrial epithelial cells predicts cumulative live birth in women aged 35 and older

, 2023
ObjectiveTo evaluate the attachment rate of a human embryonic stem cell–derived trophoblastic spheroid onto endometrial epithelial cells in predicting the cumulative live birth rate of an in vitro fertilization (IVF) cycle.DesignA prospective ...
Ernest Hung Yu Ng, Andy Chun Hang Chen, Mei Ting Lam, Lam, Mei Ting, Yin Lau Lee, Raymond Hang Wun Li, Fong, Sze Wan, Chen, Andy Chun Hang, Ruan, Hanzhang, Lee, Kai Chuen, Lee, Kai Fai, Yue, Chaomin, Ng, Ernest Hung Yu, Kai Fai Lee, William Shu Biu Yeung, Li, Raymond Hang Wun, Lee, Yin Lau, Yeung, William Shu Biu, Kai Chuen Lee, Sze Wan Fong, Chaomin Yue, Hanzhang Ruan   +21 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The effect of female body mass index on cumulative live birth rate in women undergoing in vitro fertilization according to age

Medicine
The aim of this study was to explore the impact of female body mass index (BMI) on cumulative live birth rates (CLBR) in patients treated with in vitro fertilization (IVF) and embryo transfer. A total of 2377 patients who visited the Reproductive Medical
Shu-Xia Ma, Rui-Rui Li, Lu Ouyang, Lin Li   +3 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source