Results 101 to 110 of about 9,723,781 (298)

Development and Application of Biomonitoring Equivalents for Interpreting Biomonitoring Data in a Human Health Risk Context [PDF]

, 2009
Increasingly sensitive analytical tools allow measurement of trace concentrations of chemicals in human biologic media in persons from the general population. Such data are being generated by biomonitoring programs conducted by the U.S.
Dep IRAS, Hays, S.M., Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core   +1 more source

Particulate air pollution, coronary heart disease and individual risk assessment: a general overview. [PDF]

, 2009
Both long-term and short-term exposure to air pollution is associated with a marked increase in cardiovascular morbidity and mortality because of the coronary syndrome and its complications.
Twickler, M., Cramer, Maarten Jan, Doevendans, Pieter, Dep IRAS, Hassing, C., Risk Assessment of Toxic and Immunomodulatory Agents, Doevendans, P.A., Kastelein, John, Cassee, F.R., Cramer, M.J.M., Twickler, Marcel, Brunekreef, B., Hassing, Carlijne, Brunekreef, Bert, Kastelein, J., Cassee, Flemming   +15 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans [PDF]

, 2012
The role that in vitro systems can play in toxicological risk assessment is determined by the appropriateness of the chosen methods, with respect to the way in which in vitro data can be extrapolated to the in vivo situation.
Testai, E., Dep IRAS, Daneshian, M., Zurlo, J., Kramer, N.I., Leist, M., Risk Assessment of Toxic and Immunomodulatory Agents, Vandebriel, R.J., Goldberg, A.M., Seibert, H., Heneweer, M., Blaauboer, B.J., Boekelheide, K., Dingemans, M.M.L., Yager, J.D., Clewell, H.J., Jaworska, J.   +16 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Combined use of food preservatives in China and its theoretical cumulative risk assessment

Zhongguo shipin weisheng zazhi
ObjectiveTo study the combined use of preservatives in food in China and to evaluate the intake level of common preservatives and their cumulative exposure risk.MethodsThe exposures of common preservatives were calculated by simple distribution ...
OU Tong, CHANG Jiongjiong, LI Qiang, YONG Ling, XIAO Xiao, LI Shanyawen, SONG Yan   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Using Information on Exposure to Characterizing Risks to Human Health from Concurrent Exposures to Multiple Chemicals [PDF]

, 2012
This thesis explores the concept of using exposure information to understand, organize, and manage the risks associated with cumulative exposures to chemicals (exposures to multiple chemicals from multiple sources).
Dep IRAS, Mr Price, PSP, Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core   +1 more source

Combined use of food preservatives with other functional additives in China and their cumulative risk assessment

Zhongguo shipin weisheng zazhi
ObjectiveThe combined use of food preservatives and other functional additives in China was analyzed， and the exposure assessment and cumulative risk assessment based on the detection content were carried out for the combination of common preservatives ...
HUANG Zizhao, ZHANG Weichunbai, YONG Ling, OU Tong, LI Jianwen, PAN Feng, WEI Qinzhi, SONG Yan   +7 more
doaj   +1 more source

Convergent endocrine disruption by emerging food-borne contaminants: towards a Pathway Disruption Load (PDL) [PDF]

Exploration of Foods and Foodomics
A variety of endocrine-relevant contaminant categories are now chronically co-exposed to the human population through the food chain, including direct dietary intake, packaging migration, and drinking-water pathway, such as per- and polyfluoroalkyl ...
Ayodeji Johnson Ajibare, Tolulope Adeniji-Kester, Olabode Oluwadare Akintoye, Isaac Adeola Oriyomi, Abraham Olufemi Asuku   +4 more
doaj   +1 more source