Results 81 to 90 of about 9,723,781 (298)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Applying a cumulative risk framework to drinking water assessment: a commentary

Environmental Health, 2019
The health risks of drinking water contaminants and the economic benefits of drinking water standards are typically assessed one chemical at a time, an approach that misses the health impacts of co-occurring contaminants in drinking water. In contrast, a
Tasha Stoiber, Alexis Temkin, David Andrews, Chris Campbell, Olga V. Naidenko   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Uncertainties in risk assessment of dioxin-like compounds : A focus on systemic relative potencies and species differences [PDF]

, 2014
This thesis describes experimental work undertaken to reduce uncertainties in the risk assessment of dioxin-like compounds. The toxic equivalency factor (TEF) approach is the most commonly used method for assessing the risk of complex mixtures of dioxin ...
Dep IRAS, van Ede, K.I., Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core  

Mapping Cumulative Environmental Risks: Examples from The EU NoMiracle Project [PDF]

, 2010
We present examples of cumulative chemical risk mapping methods developed within the NoMiracle project. The different examples illustrate the application of the concentration addition (CA) approach to pesticides at different scale, the integration in ...
Jan Groenwold, Groenwold, J., Rallo, R., Rallo, Robert, Uwe Schlink, Kathrin Strebel, Robert Rallo, Serenella Sala, Pistocchi, Alberto, Alberto Pistocchi, Lahr, Joost, Joost Lahr, Strebel, Kathrin, Marelys Mujica, Lahr, J., Vizcaino, P., Schlink, Uwe, Vighi, M., Mujica, Marelys, Sala, S., Vighi, Marco, Sala, Serenella, Pilar Vizcaino, Schlink, U., Loos, Mark, Ragas, Ad M. J., Ad M. J. Ragas, Mark Loos, Strebel, K., Vizcaíno Martínez, María Pilar, Pistocchi, A., Marco Vighi, Groenwold, Jan, Mujica, M., Loos, M., Ragas, A.M.J.   +35 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Quantitative exposure assessment in community-based studies [PDF]

, 2012
Occupational epidemiology focuses on the associations between exposures at the workplace and disease outcomes, essentially concerned with the prevention of disease.
Peters, S.M., Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core   +1 more source

Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system

EFSA Journal, 2020
A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the nervous system: brain and/or erythrocyte ...
European Food Safety Authority (EFSA), Peter S Craig, Bruno Dujardin, Andy Hart, Antonio F Hernández‐Jerez, Susanne Hougaard Bennekou, Carsten Kneuer, Bernadette Ossendorp, Ragnor Pedersen, Gerrit Wolterink, Luc Mohimont   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessment of occupational risks from human health and environmental perspectives: a new integrated approach and its application using fuzzy BWM and fuzzy MAIRCA

, 2020
improving their operations with a view to human health and environmental awareness. Many methods with different rationales have been existed in the literature to prioritize hazards according to their risk levels and to mitigate their consequences.
Ak, M. Fatih, Gül, Muhammet, Ak, Muhammet Fatih   +2 more
core   +1 more source