Results 71 to 80 of about 9,723,781 (298)

Pretrial Risk Assessments and Cumulative Disadvantage

, 2023
124 pages ; This is a study of street-level bureaucrats, pretrial risk assessments, unintended consequences, and perverse effects in Virginia’s criminal legal system. The overarching questions motivating this work are: how do legal actors interact with risk assessments, and what effects do those interactions have on individual outcomes, agency dynamics,
openaire   +2 more sources

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mode of Action Frameworks in Toxicity Testing and Chemical Risk Assessment [PDF]

, 2009
Recently, legislative mandates worldwide are requiring systematic consideration of much larger numbers of chemicals. This necessitates more efficient and effective toxicity testing, as a basis to be more predictive in a risk assessment context.
Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Meek, B.   +2 more
core   +1 more source

Advancing EIA framework for deep-sea mining: a critical review of current regulations and proposals

Frontiers in Marine Science
On June 25, 2021, Nauru informed the Council of International Seabed Authority that its sponsored entity Nauru Ocean Resources Inc. intended to apply for approval of a plan of work for exploitation in the international seabed area and requested the ...
Yu Ning, Yu Ning
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A closer look at bioaccumulation of petroleum hydrocarbon mixtures in aquatic worms. [PDF]

, 2010
Petroleum hydrocarbons (oils) are ubiquitous in the aquatic environment, and adequate risk assessment is thus essential. Bioaccumulation plays a key role in risk assessment, but the current knowledge on bioaccumulation of oils is limited. Therefore, this
Dep IRAS, Jonker, M.T.O., Risk Assessment of Toxic and Immunomodulatory Agents, Muijs, B.   +3 more
core   +1 more source

Progress in cumulative risk assessment of human health from combined exposure to environmental pollutants

Shanghai Jiaotong Daxue xuebao. Yixue ban
The combined exposure to environmental pollutants can result in unanticipated adverse effects on human health, and how to compare and assess these effects has always been a matter of great concern for the international community.
CHENG Xiaomeng, ZHANG Yan, GAO Yu, TIAN Ying   +3 more
doaj   +1 more source

Scientific Opinion on the relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in food

EFSA Journal, 2013
The European Food Safety Authority (EFSA) asked the Panel on Plant Protection Products and their Residues (PPR Panel) to develop a Scientific Opinion on the relevance of dissimilar mode of action and its appropriate application for cumulative risk ...
EFSA Panel on Plant Protection Products and their Residues (PPR)
doaj   +1 more source