Results 131 to 140 of about 965,886 (297)

Non-carcinogenic and cumulative risk assessment of exposure of kitchen workers in restaurants and local residents in the vicinity of polycyclic aromatic hydrocarbons. [PDF]

Sci Rep, 2023
Shamsedini N, Dehghani M, Samaei MR, Nozari M, Bahrany S, Tabatabaei Z, Azhdarpoor A, Hoseini M, Fararoei M, Roosta S.   +9 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Framework for Cumulative Risk Assessment: Exploring the Carcinogenic Effects of Chemical Mixtures. [PDF]

Environ Health Perspect, 2021
Schmidt S.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Risk assessment of specific heavy metals cumulative exposure to dendrobium officinale in nine provinces in China

Zhongguo shipin weisheng zazhi
ObjectiveTo understand the consumption of dendrobium officinale， by residents in nine Chinese provinces， and assess the cumulative levels of exposure related to four heavy metals （lead， cadmium， mercury， and arsenic） in dendrobium officinale consumers ...
HUANG Yalin, BAO Huihui, QIU Xuejiao, LI Jianwen, ZHANG Lei, ZHANG Shounan, LI Qi, CAO Pei, QIN Si   +8 more
doaj   +1 more source

Are Phthalate Exposure Related to Oxidative Stress in Children and Adolescents with Asthma? A Cumulative Risk Assessment Approach. [PDF]

Antioxidants (Basel), 2022
Huang PC, Cheng PK, Chen HC, Shiue I, Chang WT, Huang HI, Chang JW, Wang IJ.   +7 more
europepmc   +1 more source

The impact of reasons for credit rating announcements in equity and CDS markets [PDF]

, 2009
Over the last four decades the literature on bond rating changes and its effects on security prices increased significantly with almost all studies not controlling for the respective reason for those.
Imbierowicz, Björn, Wahrenburg, Mark
core  

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach

Scientific Reports
Cumulative risk assessment is significant for evaluating the combined exposure to multiple substances, but its widespread acceptance and application have been limited due to the complexity of clarifying and assessing actual exposure.
Jiahui Chen, Jingrong Chen, Mintao Li, Ping Feng, Mei Qin, Ting Chen, Shuquan Luo, Jian Zhao, Xiaofeng Yan, Jinyao Chen, Xuemei Lian, Huadong Zhang, Jiao Huo   +12 more
doaj   +1 more source