Results 31 to 40 of about 27,868 (282)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Until it hurts? Epidemiology of musculoskeletal pain in youth sports

Journal of Physical Fitness and Sports Medicine, 2017
Sports and physical activity provide multiple social and health benefits to participants, but may also increase the risk of developing musculoskeletal pain and injuries, especially in skeletally immature adolescents.
Masamitsu Kamada, Takafumi Abe, Jun Kitayuguchi   +2 more
doaj   +1 more source

Prevalence of trauma, PTSD and psychotic symptomatology in relation to suicidality and quality of life in substance users

Dialogues in Clinical Neuroscience & Mental Health, 2020
The present cross-sectional study aims to investigate trauma (early and cumulative), Post-Traumatic Stress Disorder, manifestation of psychotic symptomatology, quality of life and suicidality in recipients of Substitution Program services.
Theodora Christia, Adamantia Kazani, Stylianos Stylianidis, Mariam Tepetzikioti, Maria Tritari, George Tzeferakos   +5 more
doaj   +1 more source

Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS). Methods This study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific ...
Nicole Shelley, Bradley Judge, Dmitriy A. Yablonskiy, Robert T. Naismith, Matthew R. Brier, Anne H. Cross   +5 more
wiley   +1 more source

Clinical Phenotyping of Long COVID Patients Evaluated in a Specialized Neuro‐COVID Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To report Long COVID characteristics and longitudinal courses of patients evaluated between 4/14/21–4/14/22 at the University of Pennsylvania Neurological COVID Clinic (PNCC), including clinical symptoms, neurological examination findings, and neurocognitive screening tests from a standardized PNCC neurological evaluation approach ...
Luana D. Yamashita, Neel Desai, Abigail R. Manning, Caitlin Pileggi, Sara Manning Peskin, Danielle K. Sandsmark, Dennis L. Kolson, Matthew K. Schindler   +7 more
wiley   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

The daily living experience of nursing woman-workers that display work related musculoskeletal disorders (WRMD) at optical heideggerian existential phenomenology

Online Brazilian Journal of Nursing, 2007
In this qualitative study of phenomenologic approach, I have searched for understanding the living experience of nursing woman-workers that display work related musculoskeletal disorders (WRMD).
Patrícia Campos Leite, Miriam Aparecida Barbosa Merighi, Arlete - Silva   +2 more
doaj   +2 more sources

Factors associated with presenteeism in nursing workers

Revista Brasileira de Enfermagem
Objective: to analyze factors associated with presenteeism in nursing workers with sociodemographic variables, health and work conditions, productivity and musculoskeletal symptoms.
Bruno da Silva Santos, Fernanda Ludmilla Rossi Rocha, Juliano Bortolini, Fábio de Souza Terra, Marília Duarte Valim   +4 more
doaj   +2 more sources

Childhood trauma among adult patients with mental illness in south-western Uganda: A hospital-based study

SSM - Mental Health, 2023
Introduction: Childhood trauma plays a central role in the long-term outcomes and quality of life of adults with mental disorders. Its burden among patients receiving mental health care in rural health facilities has not been established formally.
Bives Mutume Nzanzu Vivalya, Benedict Akimana, Scholastic Ashaba   +2 more
doaj  

Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik, Benjamin Barthel, Nanna R. Andersen, Sofie V. Skriver, Alan J. Russell, John Vissing   +5 more
wiley   +1 more source