Results 51 to 60 of about 37,333 (261)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

4491 Cumulative Childhood Trauma Load Across Race in Individuals with Alcohol Use Disorder

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Our objective was to investigate racial differences in experiencing multiple categories of childhood trauma (CT) and the differential impact on alcohol use in individuals with alcohol use disorder (AUD). We hypothesized that there would
Nia Byrd, Bethany L. Stangl, Melanie L. Schwandt, Nancy Diazgranados, Vijay A. Ramchandani   +4 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

The return to work of individuals with musculoskeletal disorders

Cadernos Brasileiros de Terapia Ocupacional, 2017
Introduction: The return to work is a complex process and there are some difficulties and challenges to workers with RSI/WRMSD. Objective: To investigate the experiences during the process of return to work of individuals affected with work-related ...
Bárbara Militelo Pestana, Janaína Bussola Montrezor Valença, Ágatha Eglê Moreira Graeser, Maria do Carmo Baracho de Alencar   +3 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Low sensitivity of three-phase bone scintigraphy for the diagnosis of repetitive strain injury

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: The diagnosis of repetitive strain injury (RSI) is subjective and solely based on clinical signs and physical examination. The aim of this paper was to assess the usefulness of three-phase bone scintigraphy (TPBS) in diagnosing RSI.
Bárbara Juarez Amorim, Elba Cristina Sá de Camargo Etchebehere, Graciella Dalla Torre, Mariana da Cunha Lopes de Lima, Allan de Oliveira Santos, Celso Darío Ramos, Luiz Ricardo Gonzalez, José Inácio Oliveira, Edwaldo Eduardo Camargo   +8 more
doaj   +1 more source

Quantitative Models for Prediction of Cumulative Trauma Disorders Applied to the Maquiladora Industry. [PDF]

Int J Environ Res Public Health, 2021
Cázares-Manríquez MA, Camargo-Wilson C, Vardasca R, García-Alcaraz JL, Olguín-Tiznado JE, López-Barreras JA, García-Rivera BR.   +6 more
europepmc   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

TRASTORNOS MUSCULOESQUELÉTICOS EN PROFESORES: ESTUDIO DE ENFERMERÍA DEL TRABAJO

Ciencia y Enfermería
Este estudio tuvo como objetivo identificar las características del trabajo y sus implicaciones en la aparición de trastornos musculoesqueléticos en profesores.
Marta Regina Cezár-Vaz, Marlise Capa Verde De Almeida, Laurelize Pereira Rocha, Anelise Miritz Borges, Luana De Oliveira Severo, Clarice Alves Bonow   +5 more
doaj   +1 more source