Results 61 to 70 of about 37,333 (261)

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Construção e desconstrução das identidades masculinas entre trabalhadores metalúrgicos acometidos de LER/DORT

Cadernos de Saúde Pública, 2018
Resumo: Este estudo teve por objetivo compreender como trabalhadores metalúrgicos vivenciam a incapacidade prolongada para o trabalho por lesões por esforços repetitivos/distúrbios osteomusculares relacionados ao trabalho (LER/DORT) e o impacto do ...
Jorge Henrique Santos Saldanha, Mônica Angelim Gomes de Lima, Robson da Fonseca Neves, Jorge Alberto Bernstein Iriart   +3 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Pesquisa avaliativa em reabilitação profissional: a efetividade de um serviço em desconstrução

Cadernos de Saúde Pública
O texto aborda a avaliação dos resultados de um modelo assistencial inovado, no período de 1995 a 1997, para adoecidos por LER/DORT, desenvolvido no Centro de Reabilitação Profissional de Campinas do Instituto Nacional de Seguro Social.
Mara Alice Batista Conti Takahashi, Ana Maria Canesqui   +1 more
doaj  

Cumulative adverse childhood experiences and risk of mental disorders: A systematic review and meta-analysis

Acta Psychologica
Background: Adverse childhood experiences (ACEs) are consistently linked to poor mental health across the lifespan. However, the cumulative impact of multiple ACEs and the extent to which methodological and population factors shape these associations ...
Emmanuel Annor, Madeline Pollak, Dhanalakshmi Ramasamy   +2 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Musculoskeletal pain in Dentistry students [PDF]

Revista Brasileira em Promoção da Saúde, 2010
Objective: To investigate the frequency of musculoskeletal pain in dental students. Methods: A descriptive study of observational and cross-sectional approach in which was used an Ergonomics and Posture Questionnaire for Dentists adapted by the ...
Rosane Batista e Silva, Ricardo Alexandre GuerraVieira, Anniele Martins Silva, Gisela Rocha de Siqueira   +3 more
doaj  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

COVID-19 pandemic in minor psychiatric disorders among mobile emergency service workers: cohort

Revista Brasileira de Enfermagem
Objectives: to measure the effect of the COVID-19 pandemic on minor psychological disorders among Mobile Emergency Care Service workers. Methods: this was a retrospective and prospective cohort study conducted in a southern Brazilian capital.
Natasha da Silva Indruczaki Guedes, Polla Victória Paim Rodrigues Finckler, Silviamar Camponogara, Keyla Cristiane do Nascimento, Juliana Petri Tavares, Daiane Dal Pai   +5 more
doaj   +2 more sources