Results 31 to 40 of about 111,887 (303)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

The influence of information on the prevention of occupational risks and ergonomic requirements in the development of non-traumatic osteomuscular diseases of the shoulder – a pilot study

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2019
Objectives Shoulder pain associated with upper limb musculoskeletal disorders is an important health problem in clinical practice due to its high prevalence, frequent consultations in primary healthcare and occupational health.
Gloria M. Rodríguez-Blanes   +4 more
doaj   +1 more source

Youth Incarceration, Health, and Length of Stay [PDF]

open access: yes, 2017
For youth from marginalized communities, the pathway into the juvenile justice system occurs against a backdrop of disproportionately high levels of stress, complex trauma, and adverse childhood experiences.
González, Thalia
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Musculoskeletal disorders and perception of working conditions: A survey of Brazilian dentists in São Paulo

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2017
Objectives: To investigate the prevalence of work-related musculoskeletal disorders amongst dentists who work in public clinics in São Paulo, Brazil, to investigate their awareness of the presence of risk factors in the workplace, disability due to pain,
Artênio José Ísper Garbin   +4 more
doaj   +1 more source

Reducing Cumulative Trauma Disorders [PDF]

open access: yesAAOHN Journal, 1994
1. Cumulative trauma disorder can be reduced by applying four ergonomic approaches: applying anthropometric data, reducing the number of repetitions, reducing the force required, and eliminating awkward postures as much as possible. 2. Selecting the proper work surface height will help reduce fatigue, pain, and discomfort and will allow the employee to
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prevalence of trauma, PTSD and psychotic symptomatology in relation to suicidality and quality of life in substance users

open access: yesDialogues in Clinical Neuroscience & Mental Health, 2020
The present cross-sectional study aims to investigate trauma (early and cumulative), Post-Traumatic Stress Disorder, manifestation of psychotic symptomatology, quality of life and suicidality in recipients of Substitution Program services.
Theodora Christia   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

A comparison of PTSD and traumatic event rates in a clinical sample of non-refugee immigrants and native-born individuals with a psychotic disorder: a case-control study

open access: yesEuropean Journal of Psychotraumatology, 2023
Background: Migration is a multi-stage social process linked to traumatic event exposure and a notably increased risk of psychosis. Although these conditions affect refugee and non-refugee immigrants, prior trauma research has focused mainly on the ...
Amira Trabsa   +8 more
doaj   +1 more source

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