Results 211 to 220 of about 9,893 (241)

AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model. [PDF]

J Neuroinflammation
Ricciardi L, Di Marco F, Decrop M, Di Stefano J, Kakunuri T, van Rijswijk J, Vidas-Guscic N, El Ouaamari Y, Bufi AA, Van Spilbeeck I, Van Audekerke J, Faghel C, Bartholomeus E, Lion E, Cools N, Van Laere S, Cicalini I, De Laurenzi V, FitzGerald U, Pieragostino D, Huard B, Del Boccio P, Ponsaerts P, Verhoye M.   +23 more
europepmc   +1 more source

Copaxone treatment in the cuprizone mouse model

, 2018
Garea-Rodriguez, Enrique, Stadelumun, C., Merklei, D., Brueck, Wolfgang   +3 more
openaire   +1 more source

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CD44 expression in the cuprizone model

Brain Research, 2020
Numerous studies report that changes in extracellular matrix components and receptors, such as CD44, contribute to immune cell recruitment and thus lesion formation in multiple sclerosis (MS). In the present study, we used the cuprizone model to elucidate the expression pattern of CD44 in a toxin-induced MS model.
Christin Reinbach, Maria-Sophia Stadler, Nicolas Pröbstl, Uta Chrzanowski, Christoph Schmitz, Markus Kipp, Tanja Hochstrasser   +6 more
openaire   +2 more sources

The cuprizone model for demyelination

Acta Neurologica Scandinavica, 2008
Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination.
O, Torkildsen, L A, Brunborg, K-M, Myhr, L, Bø   +3 more
openaire   +2 more sources

Cuprizone neurotoxicity, copper deficiency and neurodegeneration

NeuroToxicology, 2010
Cuprizone is used to obtain demyelination in mice. Cuprizone-treated mice show symptoms similar to several neurodegenerative disorders such as severe status spongiosus. Although it has a simple chemical formula, its neurotoxic mechanism is still unknown. In this work, we examined both physico-chemical properties and biological effects of cuprizone. Our
BENETTI, FEDERICO, VENTURA, MARCELLO, SALMINI, BENEDETTA, CEOLA, STEFANO, CARBONERA, DONATELLA, MAMMI, STEFANO, ZITOLO A, D'ANGELO P, URSO E, MAFFIA M, SALVATO, BENEDETTO, SPISNI E.   +11 more
openaire   +4 more sources

Investigation of Cuprizone Inactivation by Temperature

Neurotoxicity Research, 2017
Animal models, such as cuprizone (bis-cyclohexanone oxaldihydrazone) feeding, are helpful to study experimental demyelination and remyelination in the context of diseases like multiple sclerosis. Cuprizone is a copper chelator, which when supplemented to the normal food of C57BL/6J mice in a concentration of 0.2% leads to oligodendroglial loss ...
Sandra, Heckers, Nadine, Held, Jessica, Kronenberg, Thomas, Skripuletz, Andre, Bleich, Viktoria, Gudi, Martin, Stangel   +6 more
openaire   +2 more sources

Synthesis and structural characterization of copper–cuprizone complexes

Dalton Transactions, 2022
The chemistry of copper with cuprizone has challenged chemists for over 70 years. We characterize the classical ‘blue’ product, containing Cu(iii) and hydrolyzed cuprizone, and a green multimeric Cu(ii) product, containing unhydrolyzed cuprizone.
M. Jake Pushie, Kelly L. Summers, Kurt H. Nienaber, Ingrid J. Pickering, Graham N. George   +4 more
openaire   +2 more sources