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Unravelling the chemical nature of copper cuprizone
Dalton Transactions, 2007During the last 50 years, formation of the highly chromogenic copper cuprizone complex has been exploited for spectrophotometric determinations of copper although the precise chemical nature of the resulting species has never been ascertained; we eventually show here, in contrast to current opinion, that copper cuprizone is a copper(III)complex.
MESSORI, LUIGI +5 more
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Acta Neuropathologica, 2009
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the central nervous system and represents the most common neurological disorder in young adults in the Western hemisphere. There are several well-characterized experimental animal models that allow studying potential mechanisms of MS pathology.
Kipp, Markus +4 more
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Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the central nervous system and represents the most common neurological disorder in young adults in the Western hemisphere. There are several well-characterized experimental animal models that allow studying potential mechanisms of MS pathology.
Kipp, Markus +4 more
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Ultrastructural changes of cuprizone encephalopathy in mice
Toxicology and Applied Pharmacology, 1971Abstract The ultrastructural features of the encephalopathy induced by chronic feeding of cuprizone in the white matter of the cerebellar medulla of mice were characterized. Mice were fed a diet of 0.5% cuprizone for 8 wk and, under anesthesia, were perfused with 6% buffered glutaraldehyde.
R D, Hemm, W W, Carlton, J R, Welser
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Behavioural and histological changes in cuprizone-fed mice
Brain, Behavior, and Immunity, 2020Feeding cuprizone (CPZ) to mice causes demyelination and reactive gliosis in the central nervous system (CNS), hallmarks of some neurodegenerative diseases like multiple sclerosis. However, relatively little is known regarding the behavioural deficits associated with CPZ-feeding and much of what is known is contradictory.
Sen, Monokesh (R19837) +4 more
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Interferon-γ Protects against Cuprizone-Induced Demyelination
Molecular and Cellular Neuroscience, 2000Evidence suggests that interferon-gamma (IFN-gamma), a proinflammatory cytokine secreted by activated T lymphocytes, contributes a deleterious effect to immune-mediated demyelinating disorders such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
X, Gao +5 more
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The cuprizone model: regional heterogeneity of pathology
APMIS, 2012The cuprizone model is a model of de‐ and remyelination secondary to oligodendrocyte death, likely to be mediated by an inhibition of mitochondrial function. The aim of this study was to characterize histopathological changes associated with de/remyelination in grey and white matter at different disease stages in C57Bl/6 mice after per oral ...
Stig, Wergeland +4 more
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Probenecid-treatment reduces demyelination induced by cuprizone feeding
Journal of Chemical Neuroanatomy, 2017Recent experiments showed that a pannexin-1 inhibitor, probenecid, reduced clinical symptoms in the murine experimental autoimmune encephalomyelitis when applied during the initial phase of neuronal inflammation. An inflammatory component is also present in a toxically induced inflammation and demyelination using cuprizone diet.
Nadine, Hainz +7 more
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Cuprizone‐induced demyelination in CNP::GFP transgenic mice
Journal of Comparative Neurology, 2010AbstractCuprizone (bis‐cyclohexanone oxaldihydrazone) was previously shown to induce demyelination in white matter enriched brain structures. In the present study we used the cuprizone demyelination model in transgenic mice expressing the enhanced green fluorescent protein (GFP) under the 2′‐3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPase) promoter ...
Lucas, Silvestroff +5 more
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Variation in the Response of Mice to Cuprizone
Research in Veterinary Science, 1973Summary Weanling mice from 2 populations were fed 1% cuprizone for 59 days. During the experiment an assessment was made of the body weight and clinical condition of these mice and equivalent controls. The weight gain and behaviour of the control mice were similar throughout.
S, Elsworth, J M, Howell
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Pathological changes in mice with long term cuprizone administration
Neurochemistry International, 2019Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In MS, a long disease duration is known to be a strong risk factor for converting the clinical course of the disease from relapse remitting MS to secondary progressing MS.
Taichi, Nomura +4 more
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