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Cuprizone neurotoxicity in the rat: Morphologic observations
Journal of the Neurological Sciences, 1988Weanling male Wistar rats fed a diet containing 0.5-2% cuprizone developed intramyelinic edema of the cerebellar white matter, hilum of the dentate nucleus and superior cerebellar peduncle. Oligodendrocytes in these regions showed hyperchromatic nuclei and abnormally dense cytoplasm, with an increase in the number of free ribosomes and enlargement of ...
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Pain Responses in C57BL/6 Cuprizone Fed Mice
2014Pain responses in C57BL/6 cuprizone fed mice Introduction: Demyelination is a known cause of neuropathic pain in diseases such as multiple sclerosis (MS). Pathophysiology of central neuropathic pain in MS patients is considered to be a consequence of deterioration of myelin sheaths.
Fenrich, Matija +3 more
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A characterization of cuprizone-induced giant mouse liver mitochondria
Journal of Bioenergetics and Biomembranes, 1990Cuprizone affects the liver of treated mice in a random manner, causing no appreciable change in some cases and inducing the formation of megamitochondria with altered properties in others. Lack of a full appreciation of this variability may be at the origin of some discrepancies in published work dealing with the properties of cuprizone mouse liver ...
V, Petronilli, M, Zoratti
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Histopathological Similarities between Scrapie and Cuprizone Toxicity in Mice
Nature, 1971PREVIOUS work with scrapie led us to conclude1 that the transmissible agent was unlikely to be a conventional virus. We have presented evidence2 that the transmissible agent may be, or may be associated with, a small basic protein (polypeptide) of the kind involved in the production of experimental allergic encephalomyelitis, and we have recorded the ...
Pattison, I H, Jebbett, J N
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Cuprizone [Bis(Cyclohexylidenehydrazide)] is Selectively Toxic for Mature Oligodendrocytes
Neurotoxicity Research, 2013Cuprizone [bis(cyclohexylidenehydrazide)]-induced toxic demyelination is an experimental animal model commonly used to study de- and remyelination in the central nervous system. In this model, mice are fed with the copper chelator cuprizone which leads to oligodendrocyte death with subsequent demyelination.
Karelle, Bénardais +8 more
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Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination
Journal of Molecular Histology, 2018Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration.
Golaleh, Noorzehi +7 more
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Beneficial Effects of Minocycline on Cuprizone Induced Cortical Demyelination
Neurochemical Research, 2010In this study, we investigated the potential of minocycline to influence cuprizone induced demyelination in the grey and white matter. To induce demyelination C57BL/6 mice were fed with cuprizone for up to 6 weeks and were analysed at different timepoints (week 0, 4, 5, 6).
Thomas, Skripuletz +7 more
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Giant Hepatic Mitochondria: Production in Mice Fed with Cuprizone
Science, 1969Giant mitochondria in hepatocytes that have the average size of nuclei can be consistently produced in the liver of weanling mice by feeding them cuprizone (bis-cyclohexanone oxaldihydrazone). The simplicity of the procedure and the consistency of the results make the feeding of cuprizone a new and useful experimental tool for the study of ...
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Effects of cuprizone on mitochondria
2023Jennifer McDonough, Sarah Sternbach
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Cuprizone-induced megamitochondrial formation and membrane fusion.
Journal of electron microscopy, 1977T, Wakabayashi +3 more
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