Results 31 to 40 of about 1,251,845 (238)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Leveraging exceptions and limitations for digital curation and online collections
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2017 Librarians wanting to use digital affordances for their patron’s and public benefit have increasingly found themselves frustrated by copyright law designed for a pre-digital era.
Patricia Aufderheide
doaj +1 more source
Investigating Curatorial Voice with Corpus Linguistic Techniques
Museum & Society, 2020 We seek to demonstrate how corpus linguistic techniques can facilitate a comprehensive account of curatorial voice in a large digitised museum catalogue and hence leverage its value as a resource for generating new knowledge about: curatorial practice ...
Andrew Salway, James Baker
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The International Journal of Screendance, 2019 My mother watched the musicals that came on television in the middle of the day in Australia in the 1970s. So we did too. She knew all the songs and sang along.
Erin Brannigan
doaj +1 more source
More benefit or harm? Moral contextualism shapes public attitudes towards social egg freezing
Frontiers in Political Science, 2022 Medical treatments at the beginning and end of human life are highly contested in public discourse. Our study reveals factors shaping the acceptance of social egg freezing (or oocyte cryopreservation) as an assisted reproduction technology (ART) in the ...
Anna Forke, Pascal Siegers
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
British Art Studies, 2019 “The Kitchen Sink Too: British Art 1945–1975” is a project led by Research Curator, Abi Shapiro at Museums Sheffield. The project undertakes research into Sheffield’s post-war visual art holdings to improve public access to the collection through a range
Abi Shapiro
doaj +1 more source
Revue d'anthropologie des connaissances, 2022 In this article, we analyze processes of conservation of artworks in a lending process. The art library in which we conducted this ethnography operates with a system that provides artworks with a capacity of movement.
Jean-Baptiste Garrocq
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source