Results 41 to 50 of about 19,754 (217)

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The International Journal of Screendance, 2016
No abstract available.
Katrina McPherson
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Scalable radiotherapy data curation infrastructure for deep-learning based autosegmentation of organs-at-risk: A case study in head and neck cancer

Frontiers in Oncology, 2022
In this era of patient-centered, outcomes-driven and adaptive radiotherapy, deep learning is now being successfully applied to tackle imaging-related workflow bottlenecks such as autosegmentation and dose planning.
E. Tryggestad, A. Anand, C. Beltran, J. Brooks, J. Cimmiyotti, N. Grimaldi, T. Hodge, A. Hunzeker, J. J. Lucido, N. N. Laack, R. Momoh, D. J. Moseley, S. H. Patel, A. Ridgway, S. Seetamsetty, S. Shiraishi, L. Undahl, R. L. Foote   +17 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Editorial: Screening the Skin: Issues of Race and Nation in Screendance

The International Journal of Screendance, 2018
No abstract available.
Melissa Blanco Borelli, Raquel Monroe
doaj   +1 more source

Guidelines for Data Acquisition, Quality and Curation for Observational Research Designs (DAQCORD)

Journal of Clinical and Translational Science, 2020
Background:High-quality data are critical to the entire scientific enterprise, yet the complexity and effort involved in data curation are vastly under-appreciated.
Ari Ercole, Vibeke Brinck, Pradeep George, Ramona Hicks, Jilske Huijben, Michael Jarrett, Mary Vassar, Lindsay Wilson   +7 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Curation is Communal: Transparency, Trust, and (In)visible Labour

International Journal of Digital Curation
Research about trust and transparency within the realm of research data management and sharing typically centres on accreditation and compliance. Missing from many of these conversations are the social systems and enabling structures that are built on ...
Halle Burns, Sand Caldrone, Mikala Narlock   +2 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Party Competition Over Democracy: Democracy as Electoral Issue in Germany

Politics and Governance
Elected leaders increasingly undermine liberal democratic institutions with the support of their voters, openly challenging liberal democratic institutions in election campaigns.
Lea Kaftan
doaj   +1 more source