Results 41 to 50 of about 1,251,845 (238)

Local Culture: Curation as an Ethnographic Process in the Contemporary Cuban Art Scene

open access: yesÍconos, 2017
This study contributes to the discussion on the production of anthropological knowledge and the visual arts in particular fields such as design, installation and curation.
Celia Irina González
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Curation is Communal: Transparency, Trust, and (In)visible Labour

open access: yesInternational Journal of Digital Curation
Research about trust and transparency within the realm of research data management and sharing typically centres on accreditation and compliance. Missing from many of these conversations are the social systems and enabling structures that are built on ...
Halle Burns   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Party Competition Over Democracy: Democracy as Electoral Issue in Germany

open access: yesPolitics and Governance
Elected leaders increasingly undermine liberal democratic institutions with the support of their voters, openly challenging liberal democratic institutions in election campaigns.
Lea Kaftan
doaj   +1 more source

How the gene ontology evolves

open access: yesBMC Bioinformatics, 2011
Background Maintaining a bio-ontology in the long term requires improving and updating its contents so that it adequately captures what is known about biological phenomena.
Leonelli Sabina   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Miscellaneous earthworm types in the Natural History Museum, London (Annelida: Oligochaet a: Megadrilacea: Eudrilidae, Lumbricidae, Megascolecidae, Moniligastridae, Octochaetidae) [PDF]

open access: yesOpuscula Zoologica Instituti Zoosystematici et Oecologici Universitatis Budapestinensis, 2014
Recently restored Lumbricus terrestris Linnaeus, 1758 neotype (NHM Register No. 1973.1.1) is described in greater detail. A lectotype is designated for Amynthas morrisi (Beddard, 1892) and an informal A. morrisi clonal speciescomplex is proposed.
Robert J. Blakemore
doaj  

O pluralismo pós-utópico da arte

open access: yesARS, 2009
Em meados dos anos 1980, alguns autores, entre eles Arthur Danto, defenderam ideias que convergiam para a proclamação do fim da arte. Esse período histórico coincidia com a explosão dos estilos pós-modernos nas artes e com os debates filosóficos e ...
Lucia Santaella
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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