Results 31 to 40 of about 1,363,609 (268)

Guidelines for Data Acquisition, Quality and Curation for Observational Research Designs (DAQCORD)

open access: yesJournal of Clinical and Translational Science, 2020
Background:High-quality data are critical to the entire scientific enterprise, yet the complexity and effort involved in data curation are vastly under-appreciated.
Ari Ercole   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Investigating Curatorial Voice with Corpus Linguistic Techniques

open access: yesMuseum & Society, 2020
We seek to demonstrate how corpus linguistic techniques can facilitate a comprehensive account of curatorial voice in a large digitised museum catalogue and hence leverage its value as a resource for generating new knowledge about: curatorial practice ...
Andrew Salway, James Baker
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Leveraging exceptions and limitations for digital curation and online collections

open access: yesLibellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2017
Librarians wanting to use digital affordances for their patron’s and public benefit have increasingly found themselves frustrated by copyright law designed for a pre-digital era.
Patricia Aufderheide
doaj   +1 more source

Curating as Research

open access: yesOn_Culture, 2016
On_Culture, No.
Gschrey, Raul   +1 more
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Red Shoes

open access: yesThe International Journal of Screendance, 2019
My mother watched the musicals that came on television in the middle of the day in Australia in the 1970s. So we did too. She knew all the songs and sang along.
Erin Brannigan
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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