Results 111 to 120 of about 46,151,458 (279)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
, 2012 Background The assessment of level severity in patient with community acquired pneumonia (CAP) is very important to determine the next management of disease. Procalcitonin (PCT) is known as one of biomarker sepsis and infection. The application of PCT is
Situmorang, Alfred Trimulfa
core
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
CURB-65 and CRB-65 Pneumonia Severity
Scores CURB-65 where a same-day urea is available, or falls back to CRB-65 where it is not, and turns the score into a site-of-care recommendation with 30-day mortality context. This document is the teaching content of the MEDiscuss CDSS tool https://mediscuss.org/cdss/curb65-pneumonia-severity, fixed for citation.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2015 Background The assessment of level severity in patient with community acquired pneumonia (CAP) is very important to determine the next management of disease.
Yani, Herlina
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2012 La neumonía adquirida en la comunidad (NAC) es una de las patologías más prevalentes en nuestro país y esta aumenta su morbimortalidad a medida que aumenta la edad de las personas. La escala CURB-65 es un índice que nos permite evaluar severidad y podría
Gálvez Mora, César Abraham
core
Van Tıp DergisiINTRODUCTION: Community-acquired pneumonia (CAP) is a major cause of infectious disease mortality and a burden on healthcare systems. CURB-65 and Pneumonia Severity Index (PSI) scores assess disease severity and guide hospitalization decisions, but their
Murtaza Kaya +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source