Results 101 to 110 of about 46,151,458 (279)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

La escala CURB-65 como índice pronóstico inicial en la enfermedad no quirúrgica [PDF]

, 2012
RESUMEN: El objetivo de este estudio fue evaluar si la escala CURB-65, índice de mortalidad validado en neumonía comunitaria, podía aplicarse también en pacientes hospitalizados en Medicina Interna, donde no se han desarrollado escalas pronósticas.
Armiñanzas Castillo, Carlos
core  

"Frailty Enhances Prognostic Accuracy Compared to CURB-65 in Community-Acquired Pneumonia"

Respiratory infections and bronchiectasis
Objective: Assessing the severity of community-acquired pneumonia (CAP) and selecting the appropriate care site is crucial for efficient management. Increased frailty is associated with poorer outcomes in both medical and surgical conditions. The objective of the study was to investigate how frailty affects the prognosis of CAP when assessed using ...
EŞME, MERT, BALCI, CAFER, HALİL, MELTEM GÜLHAN, ÖZTÜRK, ELİF, BATUR, ALİ, İdikut, Aytekin, Ceylan, Serdar, Aydın, Duygu, Çelik, Hande, KARCIOĞLU, OĞUZ   +9 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Performance of CURB-65 in predicting mortality of patients with community-acquired pneumonia in Saudi Arabia

The Journal of Infection in Developing Countries, 2017
Introduction: Various objective scoring systems were developed to standardize the approach to the designation of severity of community-acquired pneumonia (CAP). There is limited data on the use of CURB-65 among admitted CAP patients in Saudi Arabia.  Methodology: The retrospective study included CAP patients, admitted to a general hospital in Eastern ...
Al-Tawfiq, Jaffar A., Diamond, Michael, Joy, Diamond, Hinedi, Kareem   +3 more
openaire   +4 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Prognostic value of CURB-65 and pneumonia severity index (PSI) in COVID-19 pneumonia: A retrospective cohort study

Journal of Acute Disease
Objective: To validate a better scoring system between CURB- 65 and the pneumonia severity index (PSI) to predict the need for intensive care unit admission and 30-day mortality in patients with COVID-19 pneumonia.
Pankaj Kumar Jain, Varun Kumar, Pranav Kumar Bhat, Manoj Seval   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population

Diabetes, Metabolic Syndrome and Obesity, 2021
Chun-Ming Ma,1 Ning Wang,2 Quan-Wei Su,3 Ying Yan,3 Fu-Zai Yin1 1Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of China; 2Department of Internal Medicine, Hebei Medical University ...
Ma CM, Wang N, Su QW, Yan Y, Yin FZ
doaj