Results 91 to 100 of about 46,151,458 (279)

TINGKAT MORTALITAS DAN PROGNOSIS PASIEN PNEUMONIA KOMUNITAS DENGAN SISTEM SKORING CURB-65 DI RUANG RAWAT INAP PARU RSUD DR. ZAINOEL ABIDIN BANDA ACEH

JKS (Jurnal Kedokteran Syiah Kuala), 2014
Abstrak. Pneumonia komunitas (community acquired pneumonia / CAP) adalah penyakit infeksi paru yang menjadi penyebab kematian tinggi pada lanjut usia.
Novita Andayani
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluation of PC activity and each continuous variable of CURB-65 as predictors for in-hospital death of NHAP.

, 2022
PC = protein C; sBP = systolic blood pressure; RR = respiratory rate; BUN = blood urea nitrogen ...
Issei Oi (13949211), Hisako Matsumoto (419266), Nobuyoshi Hamao (13949214), Naoya Tanabe (152405), Masahiro Shirata (4126552), Isao Ito (90313), Seiichiro Imai (13949217), Yoshiro Yasutomo (13949220), Yu Hidaka (3702139), Seizo Kadowaki (13949223), Satoshi Konishi (149479), Satoshi Morita (316096), Toyohiro Hirai (307063)   +12 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dyspnea, eosinopenia, consolidation, acidemia, atrial fibrillation and confusion, urea, respiratory rate, blood pressure, and age-65 as a prognostic indicator in patients with acute exacerbation of chronic obstructive pulmonary disease

Asian Journal of Medical Sciences
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent chronic illness characterized by persistent airflow limitation. Episodes of acute worsening, known as acute exacerbations of COPD (AECOPD), represent significant clinical events ...
Radhakrishna RK , Latha V
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Additional file 1: Table S1. of Risk stratification by abbMEDS and CURB-65 in relation to treatment and clinical disposition of the septic patient at the emergency department: a cohort study

, 2016
The abbMEDS (left panel) and CURB-65 score (right panel) with risk categories. Description of data: Items and risk categories of abbMEDS and CURB-65.
Coen Stehouwer (3404234), Asselina Roest (3447728), Patricia Stassen (3447713), Jan Tegtmeier (3447731), Joris Heyligen (3447725), Astrid Lashof (3447719), Andrea Peeters (3447722), Hella Borggreve (3447734), Jeanette Duijst (3447716)   +8 more
core   +1 more source

Evaluation of suPAR as a Key Prognostic Biomarker in Patients with SARS-CoV-2 Pneumonia

Biomedicines
Background/Objectives: SARS-CoV-2 has strained healthcare systems, emphasizing the need for biomarkers to predict disease severity. Recent studies suggest that soluble urokinase plasminogen activator receptor (suPAR) is a promising marker for COVID-19 ...
Mónica Piqueras, Paula González-Jiménez, Ana Latorre, Jordi Tortosa-Carreres, Noé Mengot, Ricardo Alonso, Soledad Reyes, Isabel Amara-Elori, Francisco Sanz-Herrero, Rosario Menéndez, Raúl Méndez   +10 more
doaj   +1 more source