Results 81 to 90 of about 46,151,458 (279)

Example Curb-to-Curb, Curb-to-Catchment, Catchment-to-Outflow water disturbances.

open access: yes, 2023
Example Curb-to-Curb, Curb-to-Catchment, Catchment-to-Outflow water disturbances.
Allen Brookes (17419539)   +8 more
core   +1 more source

Comparative analysis of the prognostic significance of the CURB-65 and CRB-65 scores and their modifications in hospital mortality assessment in patients with community-acquired pneumonia

open access: yesБюллетень сибирской медицины
Background. Mortality associated with community-acquired pneumonia (CAP) continues to be a crucial health problem worldwide. Correct assessment of CAP severity and the level of care is pivotal in the disease outcome.Aim.
D. A. Vinokurova   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Prediction model for mortality in cancer patients with pneumonia: comparison with CURB‐65 and PSI

open access: yesThe Clinical Respiratory Journal, 2016
AbstractIntroduction and ObjectivesWe aimed to develop a new prediction model of mortality in cancer patients with pneumonia and to compare its performance with CURB‐65 and the Pneumonia Severity Index (PSI).MethodsActive cancer patients who were diagnosed with pneumonia at the Emergency Department (ED) from 7/1/2014 to 12/31/2014 were consecutively ...
Byung Ki, Ahn   +8 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

CURB-65 or CURB(S)-65 for community-acquired pneumonia? [PDF]

open access: yes
Background. The clinical CURB-65 score is essential for assessing severity and reducing mortality among patients with community-acquired pneumonia (CP) or at increased risk of major complications.
Creciun, Cristina, Toma, Cristina
core  

Revolutionizing Pneumonia Assessment: Modern Diagnostics and Traditional Scales

open access: yesJournal of Education, Health and Sport
Introduction and Purpose:   Pneumonia's severity demands a thorough assessment, guided by CRB-65 and CURB-65 scales. This article underscores the crucial role of accurate interpretation and effective use of these scales, emphasizing the need for a ...
Marcelina Sikora   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The role of CURB-65 score in evolution of community-acquired pneumonia [PDF]

open access: yes, 2014
State Medical and Pharmaceutical University “Nicolae Testemițanu”, Chișinău, Republic of MoldovaIntroduction: Community-acquired pneumonia (CAP) is a cause of considerable morbidity and mortality in adults, leading to high rates of hospitalizations ...
Dulgher, Maxim
core   +1 more source

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