Results 141 to 150 of about 617,754 (317)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Differences in lactational performance associated with antimicrobial treatment and clinical cure failure of metritis in dairy cows

Journal of Dairy Science
: The objective of this study was to evaluate the differences in milk production, reproductive performance, and culling associated with antimicrobial therapy and clinical cure of metritis in dairy cows.
A. Martelo Pereira, F.N.S. Pereira, P.R. Menta, E.B. de Oliveira, J.G. Prim, F.S. Lima, V.S. Machado, K.N. Galvão, C.C. Figueiredo   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Il trattamento antibiotico nelle cure palliative

, 1998
Gli AA. tracciano delle linee guida per un uso corretto degli antibiotici nell'ambito dell cure palliative, anche in pazienti neoplastici sottoposti ad intervento ...
Dmitrieva N., Scevola D., Uberti F., FAGA, ANGELA, Scevola S.   +4 more
core  

COVID-19 May Predispose to Thrombosis by Affecting Both Vascular Endothelium and Platelets

Clinical and Applied Thrombosis/Hemostasis, 2020
Erkan Cure, Medine Cumhur Cure
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Case Report: Sudden death caused by methylene chloride poisoning

Frontiers in Pharmacology
Dichloromethane is widely used as an organic solvent in aerospace, electronics, and medicine. Cases of poisoning caused by this substance are rare. Recently, we successfully treated a patient with an acute dichloromethane poisoning. During the production
Ruikai Shang, Ruikai Shang, Qiaoxin Tian, Qiaoxin Tian, Yuru Liu, Hongyu Liu, Xiangxing Zhang, Xiangxing Zhang, Mengdi Shi, Mengdi Shi, Xiangdong Jian, Xiangdong Jian, Qilu Li   +12 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How Much Practical Cure Research Do the Major Type 1 Non-Profits Fund?

, 2013
This report quantifies the major type 1 non-profits' funding for Practical Cure research. The key finding is that the four major non-profits combined allocated just two cents of every donor dollar to Practical Cure research in 2012.
Peter Miselis
core