Results 51 to 60 of about 252,041 (249)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Methodology for Determining the Correct Ultrasonic Pulse Velocity in Concrete

open access: yesBuildings
Quite often, concrete strength parameters must be determined in the shortest possible time. Due to the strong correlation between concrete’s mechanical and acoustic properties, ultrasonic devices can be used for this purpose.
Uldis Lencis   +3 more
doaj   +1 more source

Microleakage of Class II Bulk-Fill Resin Composite Restorations Cured with Light-Emitting Diode versus Quartz Tungsten-Halogen Light: An In Vitro Study in Human Teeth [PDF]

open access: gold, 2023
Jenny López-Torres   +7 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Strength and Absorption Study on Eco-Efficient Concrete Using Recycled Powders as Mineral Admixtures under Various Curing Conditions

open access: yesRecycling
Durable building materials are essential for sustainability in construction projects, aiming to reduce environmental damage from the start to the end of a building’s life. Reducing the use of Portland cement in concrete production is essential because of
Bengin M. A. Herki
doaj   +1 more source

Influence of six types of curing on fly-ash concretes

open access: yesMateriales de Construccion, 1990
This study presents the results of a series of concrete test pieces of three different mixtures: I/45A cement; Portland cement with additions; Portland with fly ash.
Marina Álvarez, Julián Salas
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Evaluation Method for the Curing Effect of Donkey Hide

open access: yesPige Kexue Yu Gongcheng
This study developed rapid method for evaluating the curing effect of donkey hide based on conductivity and Baumé degree analysis of the extract liquor from salted donkey hide.
Hui WANG   +6 more
doaj   +1 more source

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