Results 101 to 110 of about 9,707 (256)

Differential chlorophyll and carotenoid degradation underpin poor curing colour of low-quality flue-cured tobacco leaves

Frontiers in Plant Science
This study investigates the physiological basis for the inferior curing quality of low-quality flue-cured tobacco leaves. Using ‘Yunyan 300’ tobacco, we compared normal (CK), multi-fertilizer (LH), and reviving (FQ) leaves.
Shikang Fan, Shikang Fan, Weinan Huang, Yunfei Ma, Yi Chen, Yonglei Jiang, Nan Shi, Dongfang Zheng, Baole Li, Wanpeng Xi, Binbin Hu   +10 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

THE EFFECT OF RUBBER MIXING PROCESS ON THE CURING CHARACTERISTICS OF NATURAL RUBBER

, 2013
This research is aimed at studying the relationship between rubber mixing processes and curing characteristics of natural rubber. The curing characteristic analysis was carried out through a natural rubber formula having been masticated and mixed ...
Suharto Honggokusumo; Gapkindo (The Indonesian Rubber Association), Jakarta 10150, Indonesia, Hary Sulistyo; Chemical Engineering Department, Faculty of Engineering, Gadjah Mada University, Yogyakarta 55281, Indonesia, Rochmadi .; Chemical Engineering Department, Faculty of Engineering, Gadjah Mada University, Yogyakarta 55281, Indonesia, Abu Hasan; Chemical Engineering Department, State Polytechnic of Sriwijaya, Palembang 30139, Indonesia   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Curing Characteristics of 3-Dimensional Microstructures using Dynamic Pattern Projection

, 2005
Using microstereolithography technology based on dynamic pattern projection, we can fabricate micro parts with high aspect ratio. In this technology, STL file is the standard format as the same of conventional rapid prototyping system, and 3D part is ...
Choi, Kyung-Hyun, Jae Won Choi, Young Myoung Ha, Kyung Hyun Choi, Seok Hee Lee, Lee, Seok-Hee, Choi, Jae-Won, Ha, Young-Myoung   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effect of hydrothermal curing on hydration characteristics of metakaolin–CKD pastes at different temperatures in a closed system [PDF]

, 2016
Well sealed stainless steel capsule was used as a hydrothermal system to study the pozzolanic activity and hydration characteristics of metakaolin (MK)–cement kiln dust (CKD) at different temperatures (40, 80, 120 and 150 °C) up to 24 hours of ...
Ali, Gomaa A. M., Shatat, Mohamed R., Gouda, Gamal A. H., Ali, Gomaa A.M., Gouda, Gamal A.H.   +4 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source