Results 121 to 130 of about 14,212 (303)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The system of currency regulation in Ukraine in terms of liberalization of financial markets

open access: yes, 2011
Дисертацію присвячено обґрунтуванню науково-методичних положень і розробленню практичних рекомендацій щодо розвитку системи валютного регулювання в Україні в умовах лібералізації фінансових ринків.
Єпіфанова, М.А.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Features of currency regulation in modern conditions of economic development

open access: yes, 2014
У тезах досліджені інструменти валютного регулювання; надана характеристика заходів Національного банку України в сфері проведення валютних операцій; запропоновані рекомендації щодо удосконалення інструментів валютного регулювання.В тезисах исследованы ...
Деркач, Ю.Б., Derkach, J.
core  

Foreign experience in defining the legal framework, implementation and research of digital currencies

open access: yesУченые записки Российской академии предпринимательства
Digital currencies of national banks are becoming more and more tightly integrated into the modern reality. Many countries around the world are at different stages of creating, piloting and implementing digital currencies. Undoubtedly, digital currencies
E. M. Musatov   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Lenin and the Currency Competition Reflections on the NEP Experience [PDF]

open access: yes
Institutional competition stirs the interest of economists following a certain cyclical pattern. In this context, it is very interesting to look back at the experience of Lenin and the Bolsheviks of adopting monetary competition to stabilize their ...
Nikolay Nenovsky
core  

Currency, Control, and Stigma: The Complex Lives of Soviet Ukraine's Currency Prostitutes

open access: yesGender a Výzkum
This article discusses the phenomenon of currency prostitution in Soviet Ukraine in the late 1980s, a period marked by glasnost - a policy of wider dissemination of information initiated under Mikhail Gorbachev - and increased public discourse on ...
Aliesia Soloviova
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

How Long Did It Take the United States to Become an Optimal Currency Area? [PDF]

open access: yes
The United States is often taken to be the exemplar of the benefits of a monetary union. Since 1788 Americans, with the exception of the Civil War years, have been able to buy and sell goods, travel, and invest within a vast area without ever having to ...
Hugh Rockoff
core  

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