Results 141 to 150 of about 3,503,468 (338)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Currency, Control, and Stigma: The Complex Lives of Soviet Ukraine's Currency Prostitutes
Gender a VýzkumThis article discusses the phenomenon of currency prostitution in Soviet Ukraine in the late 1980s, a period marked by glasnost - a policy of wider dissemination of information initiated under Mikhail Gorbachev - and increased public discourse on ...
Aliesia Soloviova
doaj +1 more source
Financial Regulations and Rules of the Court [PDF]
, 2001 The PrepCom established a working group on financial regulations and rules, which held three sessions in November 2000, February 2001, and September 2001. While in part the models of the U.N. and draft ITLOS financial regulations could simply be followed,
Witcschel, Georg
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Journal of Applied EconomicsThis study examines how the effectiveness of capital control regulations and political performance shape the likelihood of currency crises in high- and middle-income economies.
Zia Ullah +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Bitcoin: The First Self-Regulating Currency?
LSE Law Review, 2018 This article provides an examination of regulation theory as applied to Bitcoin. Through an examination of the parallels with Ogus’ model for self-regulation, it is demonstrated that several unique features inherent to cryptocurrencies offer the benefits of regulatory oversight without the drawbacks. The article also provides a broader socio-regulatory
openaire +2 more sources
Initial Coin Offerings: Innovation, Democratization and the SEC [PDF]
, 2018 Initial coin offerings are a source of controversy in the world of startup fundraising, and their legality is, at best, an open question. Amid soaring valuations and rumors of looming SEC action, investors and issuers alike are scrambling to forge a path
Preston, Jay
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source