Results 61 to 70 of about 106,816 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Türkiye’de Para İkamesi ve Belirleyicileri (2006-2024)

Dynamics in Social Sciences and Humanities
Para ikamesi, genellikle parasal ve mali ekonomik göstergelerdeki bozulmalar nedeniyle yabancı para biriminin yerli para birimi rolünü üstlenmesi durumunda görülmektedir. Yaygın olarak ABD doları ekonomilerde rezerv para olarak tercih edildiğinden dolayı
Figen Özlü Tok, Sabri Azgün, Rabia Efeoğlu   +2 more
doaj   +1 more source

Opportunité économique de l'introduction de grignons d'olive dans l'alimentation des animaux en Tunisie [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2011
Economical impacts of the use of olive cakes in animal nutrition in Tunisia. Despite its chemical, physical and nutritional properties, which are observed also in low quality forages, some researches indicate that olive cakes can substitute at relatively
Rejeb Gharbi, F., Benarif, T.
doaj  

The Dynamics of Currency Substitution, Asset Substitution and De facto Dollarization and Euroization in Transition Countries [PDF]

This paper presents new evidence on the dynamics of dollarization and euroization for twenty-five transition countries. Estimates of the amount of foreign currency in circulation (FCC) in transition countries are used to develop a new comprehensive ...
Edgar L. Feige
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Os pilares institucionais da política cambial e a industrialização nos anos 1930

Brazilian Journal of Political Economy, 2012
The Institutional pillars of the foreign exchange policy and industrialization in Brazil in the 1930s. The 1930s constitute one milestone in the Brazilian economic development, as the accelerated industrialization process has started and became the ...
Cesar Rodrigues Van Der Laan, André Moreira Cunha, Pedro Cezar Dutra Fonseca   +2 more
doaj   +3 more sources

Il Conto di Sostituzione nel sistema monetario internazionale. (The substitution account: the problem, the techniques and the politics)

Moneta e Credito, 2013
Il presente articolo sostiene che in una prospettiva a lungo termine molti dei problemi e delle difficoltà che hanno causato il progetto conto di sostituzione ( SA) da rottamare non sono così convincenti come in precedenza sembravano essere .
S. MICOSSI, F. SACCOMANNI
doaj   +1 more source

Currency Substitution in the Transition Economy : A Case of the Czech Republic 1993-2001 [PDF]

Currency substitution appears to be an important issue affecting the design of monetary policy, especially in transition economies. Therefore, this paper strives to analyze the particular relevance of a currency substitution phenomenon for the Czech ...
Komárek Luboš, Melecký Martin
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source