Results 151 to 160 of about 3,959,172 (249)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Finite control set model predictive current control for three phase grid connected inverter with common mode voltage suppression. [PDF]

Sci Rep
Bebboukha A, Meneceur R, Chouaib L, Anees MA, Elsanabary A, Mekhilef S, Bakeer A, Harbi I, Zaitsev I, Bajaj M.   +9 more
europepmc   +1 more source

An improved synchronous reference frame current control strategy for a photovoltaic grid-connected inverter under unbalanced and nonlinear load conditions. [PDF]

PLoS One, 2017
Naderipour A, Asuhaimi Mohd Zin A, Bin Habibuddin MH, Miveh MR, Guerrero JM.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of Peanut Rust Disease (Puccinia arachidis Speg.) on Agricultural Production: Current Control Strategies and Progress in Breeding for Resistance. [PDF]

Genes (Basel)
You Y, Liao J, He Z, Khurshid M, Wang C, Zhang Z, Mao J, Xia Y.   +7 more
europepmc   +1 more source

Current control and future risk in asthma management. [PDF]

Allergy Asthma Immunol Res, 2011
Sims EJ, Price D, Haughney J, Ryan D, Thomas M.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Anticipating future learning affects current control decisions: A comparison between passive and active adaptive management in an epidemiological setting.

J Theor Biol, 2020
Atkins BD, Jewell CP, Runge MC, Ferrari MJ, Shea K, Probert WJM, Tildesley MJ.   +6 more
europepmc   +1 more source

Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle. [PDF]

J Mol Cell Cardiol, 2013
Gillespie D, Fill M.
europepmc   +1 more source