Results 91 to 100 of about 157,722 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Discussion of the technology and research in fuel injectors common rail system [PDF]

, 2017
Common rail is one of the most important components in a diesel and gasoline direct injection system. It features a high-pressure (100 bar) fuel rail feeding solenoid valves, as opposed to a low-pressure fuel pump feeding unit injectors. Third-generation
Ishak, Izuan Amin, Khalid, Amir, Maskan, Muhammad Haziq, Mohamad Yusuf, Mohamad Wafi, Sapit, Azwan, Zaman, Izzuddin   +5 more
core  

Frequency support characteristics of grid-interactive power converters based on the synchronous power controller [PDF]

, 2016
Grid-interactive converters with primary frequency control and inertia emulation have emerged and are promising for future renewable generation plants because of the contribution in power system stabilization.
Remón Rodríguez, Daniel, Rodríguez Cortés, Pedro, Zhang, Weiyi   +2 more
core   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

An estimated photocurrent controlling the inductance current of DC-DC converter for rapid MPPT pursuit with less oscillations under sudden changes in the PV chain

Heliyon
This paper focuses on simple technique from conventional techniques for the rapid maximum power point (MPP) pursuit with a less oscillations under sudden changes. In investigations, the controllability of the conventional boost converter model shows that
Geoffroy Byanpambé, Philippe Djondiné, Guidkaya Golam, Alexis Paldou Yaya, Noel Djongyang   +4 more
doaj   +1 more source

High Performance BCD Integrated Buck-Boost Converter in an AMOLED Display with Application of Self-Triggering Frequency Modulation

Advances in Electrical and Computer Engineering, 2018
Feedback control for self-triggering frequency modulation is proposed for an integrated buck-boost DC-DC converter in an AMOLED display. The goal is to reduce the ripple noise and transient time during the switching process.
KIM, H., JEON, S., CHOI, H., KIM, N.
doaj   +1 more source

Dynamics of one-cycle controlled Ćuk converters [PDF]

, 1995
One-cycle control is a nonlinear control method. The flow-graph modeling technique is employed to study the large-signal and small-signal dynamic behavior of one-cycle controlled switching converters.
Smedley, Keyue M., Ćuk, Slobodan
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Novel Unified Single-Phase Active Rectifier Topology With Advanced Operating Modes for Smart Grids

IEEE Access
Active rectifiers are of paramount importance for guaranteeing power quality in smart grids, due to their characteristics of sinusoidal current consumption and unitary power factor operation.
Vitor Monteiro, Filipe Costa, Sergio Coelho, Joao L. Afonso   +3 more
doaj   +1 more source

Study of switching transients in high frequency converters [PDF]

As the semiconductor technologies progress rapidly, the power densities and switching frequencies of many power devices are improved. With the existing technology, high frequency power systems become possible. Use of such a system is advantageous in many
Elbuluk, Malik E., Lee, Tony, Zinger, Donald S.   +2 more
core   +1 more source