Results 91 to 100 of about 652,627 (310)

Exploring factors among healthcare professionals that inhibit effective pain management in cancer patients

Central European Journal of Nursing and Midwifery, 2019
Aim: The aim of this study was to investigate differences in the barriers to good cancer pain management between physicians, nurses, and pharmacists in Jordan.
Ahmad Rajeh Saifan, Ibraheem Hassan Bashayreh, Suhair Hussni Al-Ghabeesh, Abdul-Monim Batiha, Intima Alrimawi, Mahmoud Al-Saraireh, Muwafaq Mohammad Al-Momani   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Budgetary policy of the European Communities: Squaring the circle [PDF]

, 2008
The EC's budgetary problems are coming to a head. For 1983 virtually all the Community's resources have been utilized, and there are growing fears that the Community will soon have to declare itself bankrupt unless changes are made to current policy ...
Stahl, Gerhard
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Psychopathology in Williams syndrome: the effect of individual differences across the lifespan [PDF]

, 2009
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability.
American Psychiatric Association, American Psychiatric Association, Helen F. Dodd, Jefferys D., Karmiloff-Smith A., Kaufman J., Melanie A. Porter, Mervis C. B., Pober B. R., Silverman W. K., Soni S., Switaj D. M., Woodcock R. W.   +12 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Medication treatment perceptions, concerns and expectations among depressed individuals with Type I Bipolar Disorder [PDF]

, 2009
BACKGROUND: Subjective experience of illness affects outcomes among populations with bipolar disorder (BD). This cross-sectional study combined qualitative and quantitative approaches to evaluate perceived treatment effects, concerns and expectations ...
Cassidy, Kristin A, Jenkins, Janis H, Muzina, David J, Sajatovic, Martha   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Subgroups based on fears of evaluation exhibited different social anxiety levels

BMC Psychiatry
The bivalent fear of evaluation model proposes that fear of negative evaluation (FNE) and fear of positive evaluation (FPE) are distinct but related constructs, and that social anxiety arises when they are elevated.
Yifei Zhang, Junwen Chen, Haiping Liao, Limei Zhou, Hua Zhang, Yunglung Tang, Aiyue Huang, Ofir Turel, Yin Wu, Qinghua He   +9 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source