Results 111 to 120 of about 652,627 (310)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Savings and wealth in the UK: evidence from micro-data [PDF]
The late 1980s saw a dramatic fall in personal saving rates in Britain and the United States which attracted the attention of academics and policymakers alike.
James Banks, Sarah Smith
core
Personality and phobias in adolescence: age and gender in psychopathological expressions [PDF]
, 2019 Background: Although the understanding of adolescent phobias is important, this phenomenon has thus far not been adequately researched. This report, based on clinical experience, highlights prevalent phobic phenomena linked to personality characteristics.
Alibrandi, Angela +6 more
core +3 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Egypt Adrift Five Years After The Uprising [PDF]
, 2016 As Egypt approaches the fifth anniversary of its 2011 uprising, one would be forgiven for assuming that a major challenge to the regime of President Abdel Fattah el-Sisi was gathering coherence and force, based upon its panicked and paranoid current ...
Michael Wahid Hanna
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Cogent PsychologyThe aims of this study are to examine the psychometric properties of the Barriers to Adolescents Seeking Help Scale—brief version (BASH-B) in university students and to examine sociodemographic differences in barriers to help-seeking in students with ...
Marcelo A. Crockett +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Exploring the Dynamic Costs of Process-aware Information Systems through Simulation [PDF]
, 2007 Introducing process-aware information systems (PAIS) in enterprises (e.g., workflow management systems, case handling systems) is associated with high costs.
Mutschler, B., Reichert, M.U.
core +3 more sources
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source