Results 121 to 130 of about 77,391 (263)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Somatosensory amplification and fear of cancer recurrence: Moderating effects of emotion regulation difficulties. [PDF]

Support Care Cancer
Daches S, Zohar O, Bitan S, Hasson-Ohayon I.   +3 more
europepmc   +1 more source

Revalidation of the Cyber Fear and Paranoia Scale in the Context of Current Technology

Introduction: The Cyber Paranoia and Fear Scale (CPFS) was developed in 2014 by Mason et al to measure the perception of information technology-related threats. Given the rapid evolution of digital systems, including artificial intelligence, surveillance, and data sharing, this study sought to revalidate and update the scale, resulting in the Cyber ...
Frances Greenway, Mark Weal, Emma Claire Palmer-Cooper   +2 more
openaire   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Nighttime fears in children: clinical characterisation and the user needs and preferences for a digital parent-led intervention. [PDF]

Child Adolesc Psychiatry Ment Health
Aji M, Datyner A, Gougeon J, Paravastu N, Champ SL, Lim CYS, Teng A, Hudson JL.   +7 more
europepmc   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Fear of recurrence, secondary cancers, and health problems in long-term survivors of childhood cancer: Findings from a Canadian cohort. [PDF]

Cancer
Tutelman PR, Duong J, Forbes C, Lawal OA, Fidler-Benaoudia M, Reynolds K, Giles J, Guilcher GMT, Russell B, Lebel S, Schulte FSM.   +10 more
europepmc   +1 more source

Modulation of fear by transcranial direct current stimulation (tDCS)

, 2019
Contexto: Embora a psicoterapia de exposição seja promissora no tratamento de doenças do foro nervoso e transtornos de medo como a perturbação de stress pós-traumático (PTSD), a maioria dos doentes não adquire total remissão da doença. Vários estudos sugerem a estimulação por corrente direta transcraniana (tDCS) como uma terapia capaz de facilitar o ...
openaire   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source