Results 101 to 110 of about 652,627 (310)
Globalization and European Integration: Threat or Opportunity? Perception, knowledge and policy preferences. eupinions 2018/1 of European citizens. eupinions [PDF]
, 2018 The Eurozone crisis has pushed reform of the European Union (EU) to the forefront of political debate. How can a Union of 28 states with a population of over half a billion be reformed to weather future economic crises and political challenges?
de Vries, Catherine, Hoffmann, Isabell
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Old Games, Same Concerns: Examining First Generation Video Games Through Popular Press Coverage from 1972-1985 [PDF]
, 2013 This study explores early video game technology by examining video game fears in the popular press in the 1970s and 1980s. This textual analysis examines games during their formative years, assesses risks associated with new technology, and encourages ...
Rogers, Ryan
core +1 more source
A translational perspective on neural circuits of fear extinction: Current promises and challenges
Neurobiology of Learning and Memory, 2018 Fear extinction is the well-known process of fear reduction through repeated re-exposure to a feared stimulus without the aversive outcome. The last two decades have witnessed a surge of interest in extinction learning. First, extinction learning is observed across species, and especially research on rodents has made great strides in characterising the
Sevenster, Dieuwke +2 more
openaire +6 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
FOOD PURCHASING OF DIFFERENT HOUSEHOLD TYPES IN TIMES OF RESTRICTED BUDGET [PDF]
The second German National Nutrition Survey (NVS II) provides current data for the German population. From this study, data of food purchasing in times of restricted budget will be used for a secondary analysis.
Yildiz, Juliane
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Reducing Current Taxes to Raise Future Revenue [PDF]
A government which raises taxes in the current period may induce workers to invest in finding ways to reduce their tax payments, and so may reduce the government's ability to raise revenue in the future.
Amihai Glazer
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source