Results 91 to 100 of about 2,110,146 (342)

Hydrodynamics on the lowest Landau level

open access: yes, 2014
Using the recently developed approach to quantum Hall physics based on Newton-Cartan geometry, we consider the hydrodynamics of an interacting system on the lowest Landau level.
Geracie, Michael, Son, Dam Thanh
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Fluid Bolus Therapy in Pediatric Sepsis: Current Knowledge and Future Direction

open access: yesFrontiers in Pediatrics, 2018
Sepsis is a leading cause of morbidity and mortality in children with a worldwide prevalence in pediatric intensive care units of approximately 8%.
Ben Gelbart, Ben Gelbart, Ben Gelbart
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Current Situation and Prospect of Fluid Identification in Non-Resistivity Logging

open access: yesCejing jishu
Currently resistivity logging is the primary method for fluid identification. However, accurately identifying fluid properties in formations with low porosity and permeability, significant reservoir heterogeneity, and unique mineral development poses ...
YUAN Lixin   +5 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Current Research in Fluid Mechanics [PDF]

open access: yes, 2016
Since Sir James Lighthill wrote the above essay “What is Mechanics?” for the first edition of this book, fluid mechanics, like solid mechanics, has seen remarkably rapid growth and evolution.
openaire   +1 more source

One-Way CFD/FEM Analysis of a Fish Cage in Current Conditions

open access: yesJournal of Marine Science and Engineering
This study explores the hydrodynamic behaviour of a fish cage in a steady current by employing a fluid–structure interaction model with one-way coupling between a fluid solver and a structural model.
Mariana D. Viegas   +2 more
doaj   +1 more source

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