Results 91 to 100 of about 2,070,503 (296)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A study of the couple stress on micropolar fluid flow saturating a porous medium in the presence of dust particles with hall current

Results in Physics
In this paper, the effect of couple stress on the micropolar fluid layer heated from below in the presence of dust particles through the porous medium with hall current has been investigated.
Devilal Kumawat, Devendar Kumar, Mukesh Kumar Mahala, Umar Ishtiaq, Lipi Jain, Ioan-Lucain Popa   +5 more
doaj   +1 more source

Big Bang nucleosynthesis with a stiff fluid

, 2010
Models that lead to a cosmological stiff fluid component, with a density $\rho_S$ that scales as $a^{-6}$, where $a$ is the scale factor, have been proposed recently in a variety of contexts.
Dutta, Sourish, Scherrer, Robert J.
core   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Fluid Therapy For Pediatric Patients With Diabetic Ketoacidosis: Current Perspectives

Diabetes, Metabolic Syndrome and Obesity, 2019
Muralidharan Jayashree, Vijai Williams, Rajalakshmi Iyer Division of Pediatric Emergency and Intensive Care, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, IndiaCorrespondence:
Jayashree M, Williams V, Iyer R
doaj  

Charged, conformal non-relativistic hydrodynamics

, 2010
We embed a holographic model of an U(1) charged fluid with Galilean invariance in string theory and calculate its specific heat capacity and Prandtl number.
A Adams, A Adams, A Buchel, A Donos, A Donos, A Donos, A Ghodsi, AV Galajinsky, BB Back, C Duval, C Leiva, CP Herzog, CR Hagen, D Minic, D Yamada, Daniel K. Brattan, DT Son, DT Son, E Imeroni, E Imeroni, E Witten, EG Gimon, F-L Lin, G Policastro, G Policastro, I Arsene, J Erdmenger, J Maldacena, JLF Barbon, JM Maldacena, JP Gauntlett, K Adcox, K Balasubramanian, L Mazzucato, M Alishahiha, M Hassaïne, M Hassaïne, M Rangamani, M Rangamani, M Schvellinger, O Lunin, P Kovtun, PA Horváthy, RR Nayak, S Bhattacharyya, S Bhattacharyya, S Kachru, SA Hartnoll, SF Ross, SS Gubser, T Mehen, T Schafer, V Balasubramanian, W Israel, W Israel, WD Goldberger, Y Nakayama, Y Nishida   +57 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A New Method to Improve the Sensitivity of Leak Detection in Self-Contained Fluid-filled Cables

, 2011
A method of real-time detection of leaks for self-contained fluid-filled cables without taking them out of service has been assessed and a novel machine learning technique, i.e.
Bradley, C, Hao, L, Lewin, P L, Swingler, S G   +3 more
core