Results 41 to 50 of about 7,754,773 (292)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Current harmonic suppression for PMSM driven system utilizing PI-DFT-RC controller

open access: yesEnergy Reports, 2023
The permanent magnet synchronous motor (PMSM) driven by the two-level voltage inverters features some drawbacks, such as dead-zone time, nonlinearity and other factors, leading to high amount harmonics in the stator currents.
Tianqing Yuan, Lei Yuan, Yupeng Zhang
doaj   +1 more source

Master–slave current regulation of an LCL-filter-based grid-connected inverter under variable grid condition

open access: yesThe Journal of Engineering, 2019
To ease the heavy burden of inverter control, including line current regulation, harmonic current suppression, filter resonance suppression, grid distortion suppression, phase locked loop etc., the study proposes a master–slave current regulation method ...
Yuanbin He   +4 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

A Vectorial Approach for Generation of Optimal Current References for Multiphase Permanent-Magnet Synchronous Machines in Real Time [PDF]

open access: yes, 2011
This paper deals with the generation of optimal current references for multiphase permanent-magnet (PM) synchronous machines in normal or fault mode (open-circuited phases).
KESTELYN, Xavier   +3 more
core   +1 more source

Research on Influence of Switching Angle on the Vibration of Switched Reluctance Motor

open access: yesApplied Sciences, 2022
Switched Reluctance Motors (SRMs) have emerged as a viable competitor to other established electrical machines. Although SRMs have many advantages, such as a rare earth free nature, simple structure, high fault tolerance capability and low cost ...
Xiao Ling   +3 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son   +3 more
wiley   +1 more source

Train Impedance Reshaping Method for Suppressing Harmonic Resonance Caused by Various Harmonic Sources in Trains-Network Systems With Auxiliary Converter of Electrical Locomotive

open access: yesIEEE Access, 2019
With the development of electrified railway, harmonic resonance accidents occur from time to time. Based on the mechanism of resonance, a harmonic resonance suppression radical method by impedance reshaping is proposed.
Shihui Liu   +4 more
doaj   +1 more source

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