Results 71 to 80 of about 10,375,169 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Current-mode and transimpedance-mode universal biquadratic filter using two current conveyors [PDF]
, 2017 461-468A current-mode and transimpedance-mode universal biquadratic filter with single input and multi-outputs using two current conveyors, four resistors and two grounded capacitors is presented.
Horng, Jiun-Wei +2 more
core
Analysis and Comparison of Popular Models for Current-Mode Control of Switch Mode Power Supplies [PDF]
, 2011 Current-mode control is the most popular scheme used for the operation of SMPS (Switch Mode Power Supplies). Current-mode control, also known as current-programmed mode or current-injected control is a multi-loop control scheme that has an inner loop and
Kotecha, Ramchandra M.
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The Kon-tiki venture [cartographic material] /
, 1950 Map of the Pacific Ocean showing route of Kon-tiki, Kuro Siwo and North Pacific drift, North and South Equatorial currents, Mexico current, Belt of Counter current, Peru or Humboldt's current, and South Pacific Connecting current.; "Map review no. 107, 3
Bureau of Current Affairs (London, England)
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Current Assisted Deposition Method Based on Contact Mode Atomic Force Microscope
, 2013 This paper introduces a novel AFM deposition method. In contrast to traditional method, the method in this paper has two differences. Firstly in our method AFM works in contact mode.
Liu ZL(刘增磊) +3 more
core
Analogue IC Design The current-mode approach
, 1993 The book covers the following areas: analogue integrated circuit design; current-mode circuit; current conveyor; current-mode analogue amplifier; high frequency CMOS transconductor; bipolar current mirror; dynamic current mirror; continuous-time filter ...
Toumazou, Chris
core +1 more source