Results 91 to 100 of about 8,721,544 (291)
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A non-invasive capacitive sensor strip for aerodynamic pressure measurement [PDF]
This paper presents a capacitive pressure sensor strip implemented in general purpose printed circuit board (PCB) technology based on a thin 3D structure composed of polyimide, woven glass reinforced epoxy resin (FR4) and metal layers.
A. Talamelli +21 more
core +1 more source
A New Mirroring Circuit for Power MOS Current Sensing Highly Immune to EMI
This paper deals with the monitoring of power transistor current subjected to radio-frequency interference. In particular, a new current sensor with no connection to the power transistor drain and with improved performance with respect to the existing ...
Orazio Aiello, Franco Fiori
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Environmental sensor networks [PDF]
Sensor networks for the natural environment require an understanding of earth science, combined with sensor, communications and computer technology.
Martinez, Kirk, Ong, Royan, Hart, Jane
core +1 more source
Extending the GMR Current Measurement Range with a Counteracting Magnetic Field
Traditionally, current transformers are often used for current measurement in low voltage (LV) electrical networks. They have a large physical size and are not designed for use with power electronic circuits.
Tin Yan Poon +2 more
doaj +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Resource Aware Sensor Nodes in Wireless Sensor Networks
Wireless sensor networks are continuing to receive considerable research interest due, in part, to the range of possible applications. One of the greatest challenges facing researchers is in overcoming the limited network lifetime inherent in the small ...
Merrett, Geoff V. +3 more
core +1 more source
DC Electrical Control Circuit Monitoring Technology of CRH2 EMUs
Aim at the existing problem that CRH2 DC electrical control circuit sporadic fault during operation couldnot be quickly located, an online monitoring scheme based on phase difference between magnetic modulation technology without changing the original ...
GUO Xu +3 more
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