Results 71 to 80 of about 287,801 (218)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Ripple‐Free Input Current Quadratic Converter Based on Watkin–Johnson Topology
IET Power ElectronicsThis article proposes a power electronics converter capable of providing high voltage gain while keeping a high‐quality input current ripple operating with low duty cycle. The technique for achieving the zero input current ripple at a selected duty cycle
Brenda Lizeth Reyes‐García +5 more
doaj +1 more source
Inverter-Based Resource Oscillation Source Locating via Passivity
IEEE Open Access Journal of Power and EnergyThis paper presents locating oscillation sources in inverter-based resource (IBR) integrated systems using the oscillation flow approach. The oscillation active or reactive power flow is used as an index of passivity at a particular frequency, which is ...
Zhengyu Wang +5 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Improvement of Direct Torque Control for Induction Motor with Type-2 Fuzzy
Applied SciencesDirect Torque Control (DTC) for induction motors (IMs) is an advanced method derived from Field-Oriented Control (FOC). In DTC, a voltage source inverter (VSI) is employed to directly regulate the stator flux linkage and electromagnetic torque through ...
Vinh Quan Nguyen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
PLoS ONE, 2018 IntroductionClinicians and patients face a daunting task when choosing the most appropriate probiotic for their specific needs. Available preparations encompass a diverse and continuously expanding product base, with most available products lacking ...
Jason C Sniffen +3 more
doaj +1 more source