Results 51 to 60 of about 1,686,540 (264)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Multistage converter with reduced switch voltage stress and diode current stress

IET Power Electronics
The utilization of switched inductors, involving parallel charging and series discharging of inductors, is extensively embraced in diverse DC–DC converters for attaining high voltage gain; nevertheless, the stress on switch voltage and diode current ...
M. S. Bhaskar, Umashankar Subramaniam, Dhafer Almakhles, Sivakumar Selvam, M. Muhibbullah   +4 more
doaj   +1 more source

The rhizobium symbiosis in Medicago truncatula induces a priming-like response and enhances drought tolerance

Plant Stress
Legumes can fix nitrogen (N) by symbiotic N-fixation (SNF) through association with rhizobia. However, this comes at a higher carbon cost to the host as compared to direct N fertiliser uptake. We therefore hypothesised that the energy-intensive symbiosis
Ramadoss Dhanuskodi, Yanni Dong, Cory Matthew, Tsanko Gechev, Paul P. Dijkwel   +4 more
doaj   +1 more source

Application of Pulsed eddy current technique to stress and residual stress measurement [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2014
Stress and residual stress are the main problems in the operating performance of materials. They are the principal causes of material failure and can affect life time of component. However measurement or predictions of them are typically difficult.
Abbas Habibalahi, M. S. Safizadeh
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Current progress and future perspective in combat stress reactions

Di-san junyi daxue xuebao, 2019
Soldiers in the combat field may demonstrate such non-adaptive reactions as panic disorder, narrow visual field and hearing disturbance, which potentially cause non-combat attrition and compromise the high-level cognitive functions (reasoning, judgment ...
FENG Zhengzhi, WANG Jia
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source