Results 91 to 100 of about 1,093,552 (311)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Disparate understandings of the nature, purpose and practices of reflection in teacher education
South African Journal of Childhood Education, 2018 Background: The concept of reflection is much used in teacher education in many parts of the world, including in South African teacher education policy.
Maureen Robinson, Nicolene Rousseau
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Living Curriculum of Place(s)
, 2013 This is an article for JCT Special Issue –Narrative of Curriculum in the South: Lives In-Between Contested Race, Gender, Class, and ...
Kissling, Mark T.
core +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Life, death, and ethics: medical and dental students’ attitudes on assisted dying in Austria
BMC Health Services ResearchBackground The Sterbeverfügungsgesetz (StVfG) Austria’s law on assisted dying, came into force on January 1, 2022. Since then, only limited research has examined the attitudes of medical and dental students in Austria toward assisted dying.
Carmen Trost +4 more
doaj +1 more source
A Program Based on Motivation-based Learning (ARCS) in Teaching Geography to Develop Levels of Knowledge Depth and Self-efficacy among Secondary School Students [PDF]
مجلة بحوث التعليم والإبتكارThe aim of the research is to reveal “The Effectiveness of Using program Based on Motivation-based Learning (ARCS) in Teaching Geography to Develop Levels of Knowledge Depth and Self-efficacy among Secondary School Students” The research used the ...
Nora Khaled Jalal al-Din Abul-Ela +4 more
doaj +1 more source
, 2015 The Australian Curriculum sets the expectations for what all Australian students should be taught, regardless of where they live or their background.
Australian Curriculum Assessment and Reporting Authority
core
The Pervert’s Guide to Being a Curriculum Theorist
, 2017 Reconceptualist curriculum has provided a field of study that intersects with the humanities. As a young scholar, I question my place in curriculum theory using Gilles Deleuze and Slavoj Zizek as two key entry points to ground departures (or lines of ...
Garcia, Antonio
core +1 more source