Results 81 to 90 of about 17,701,148 (336)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Exploring the Effectiveness of Whatsapp Application on Teaching and Learning at One Midlands Teacher Education Institution in Zimbabwe [PDF]

E-Journal of Humanities, Arts and Social Sciences
Generally, social media platforms have been utilised to convey personal and non-academic information. Lecturers at higher education institutions have treated social media as a non-formal means of communication.
Shoorai Konyana, Motalenyane Alfred Modise   +1 more
doaj   +1 more source

Curriculum Development in Madrasa: Exploration From Muslim Minority of West Papua [PDF]

, 2015
Muslim minority educational development was left behind to explore. The existing researches on the publication are only about Muslim majority. Therefore, it is a need to discover the existence of Muslim minority in the eastern part of Indonesia.
Wekke, I. S. (Ismail)
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A core curriculum for the continuing professional development of nurses: Developed by the Education Committee on behalf of the Council on Cardiovascular Nursing and Allied Professions of the ESC [PDF]

, 2015
Background: The European Society of Cardiology and the Council on Cardiovascular Nursing and Allied Professions share a vision; to decrease the burden of cardiovascular disease in Europe.
Astin, Felicity, Carroll, D. L., Hinterbuchner, L., Ketchell, A., Kletsiou, E., Ruppar, T., Serafin, A., Uchmanowicz, I.   +7 more
core   +1 more source

Crowdsourced Curriculum Development for Online Medical Education

Cureus, 2017
In recent years online educational content, efforts at quality appraisal, and integration of online material into institutional teaching initiatives have increased. However, medical education has yet to develop large-scale online learning centers.
Eric Shappell, T. Chan, Brent Thoma, N. Trueger, Bob Stuntz, R. Cooney, James Ahn   +6 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Evaluation of Units Established for Curriculum Support: A Collaborative Action Research

International Journal of Contemporary Educational Research
The curriculum includes educational activities that determine the struggle for survival and sustainability of a university's departments. Approaches that seek more flexible solutions and have a post-positivist understanding are needed to manage this ...
Şükran Tok, Sevda Dolapcıoglu, Kudret Öztürk   +2 more
doaj   +1 more source

課程本位閱讀測量之研究現況與發展趨勢 Review and Analysis of Research on Curriculum-based Reading Measurement

Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan, 2014
課程本位測量是監控學生學習成長及評估教學效果的方法，能適時協助教師調整教學策略，進而提升學生學習成效，為瞭解課程本位測量在閱讀領域的研究現況與發展趨勢，特以國語文與英語文閱讀為範疇，進行課程本位測量理論與實務應用的探究。主要研究目的有四，其一，瞭解課程本位測量之意義、內容與特色；其二，暸 解課程本位閱讀測量之研究現況及研究工具發展的情形；其三，瞭解國語文及英語文課程本位閱讀測量的相關研究；其四，針對課程本位閱讀測量未來研究方向及實務應用，提出若干建議。 Curriculum-based ...
吳玉珍 Yuh-Jen Wu , 劉佩雲 Pei-Yun Liu   +1 more
doaj   +1 more source