Results 71 to 80 of about 17,795,963 (336)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Investigating the Factors Strengthening Writing Skills from Grade One Elementary School Teachers' Views in Baharestan City in the Academic Year 2019-2020 [PDF]

پژوهش در روش‌های آموزش
This research was conducted with the aim of investigating the factors of strengthening writing skills from the point of view of the teachers of the first grade elementary schools in Baharestan city.
zahra Namdari, Farzaneh Vasefian, Reza Abbasi, Reihaneh Moghimiyan   +3 more
doaj   +1 more source

A multimodal model for analyzing middle school English language learners’ digital stories

International Journal of Educational Research Open, 2021
In response to the rapid development of digital literacies, this paper introduces a new multimodal framework for analyzing digital stories. Drawing on systemic functional linguistics, the four-part framework includes representational, interpersonal ...
Deoksoon Kim, Drina Kei Yatsu, Yan Li
doaj   +1 more source

The role of professional development and learning in the early adoption of the New Zealand curriculum by schools. [PDF]

, 2008
This paper is set in the context of Phase One of the Ministry of Education Curriculum Implementation Exploratory Studies (CIES) project. The schools selected for this study were considered early adopters of the revised New Zealand Curriculum (NZC ...
Ferrier-Kerr, Jenny L., Hume, Anne Christine, Keown, Paul Ashley   +2 more
core   +1 more source

What Type of Curriculum Development Models Do We Follow? An Indonesia’s 2013 Curriculum Case

Indonesian Journal of Curriculum and Educational Technology Studies, 2018
This article identifying the Indonesi’s 2013 curriculum policy from several types of curriculum development models such as Tyler, Taba, Wheeler, Nicholls & Nicholls, Tanner & Tanner, Stenhause, Cornbleth and Doll.
Dyah Palupi
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Indonesian Curriculum Development: Meaning-Based Curriculum and Competency-Based Curriculum in the Context of Teaching English Subject [PDF]

, 2014
Curriculum as the foundation of teaching and learning process coverssubject matters and students' learning experience frominside and outside of school.
Subandi, S. (Subandi)
core  

A moral-based curriculum to improve civilization and human resource development in Bangladesh

Multidisciplinary Reviews
This study investigates the necessity of creating an ethical curriculum based on Islamic ideas in Bangladesh’s educational system. Bangladesh proffers a distinctive backdrop for incorporating Islamic principles into its educational framework as a nation ...
Mahmudulhassan, W. Waston, Andri Nirwana, Soleh Amini, Muhammad Muhtar Arifin Sholeh, Muthoifin Muthoifin   +5 more
semanticscholar   +1 more source

Wiggins, G., & McTighe, J. (2005) Understanding by design (2nd ed.). Alexandria, VA: Association for Supervision and Curriculum Development ASCD

, 2017
Writers and curriculum experts Grant Wiggins and Jay McTighe present in this second edition of their best-seller Understanding by Design not only a framework to work on curriculum design in a more comprehensive, overarching, and thorough way but also a ...
Alejandro Mauricio Dávila Rubio
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source