Results 51 to 60 of about 162,667 (256)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Exploring the Effectiveness of Whatsapp Application on Teaching and Learning at One Midlands Teacher Education Institution in Zimbabwe [PDF]
E-Journal of Humanities, Arts and Social SciencesGenerally, social media platforms have been utilised to convey personal and non-academic information. Lecturers at higher education institutions have treated social media as a non-formal means of communication.
Shoorai Konyana +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Evaluation of Units Established for Curriculum Support: A Collaborative Action Research
International Journal of Contemporary Educational ResearchThe curriculum includes educational activities that determine the struggle for survival and sustainability of a university's departments. Approaches that seek more flexible solutions and have a post-positivist understanding are needed to manage this ...
Şükran Tok +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Research and Development in EducationThis study aimed to analyze the implementation of the Visible Thinking Routine (VTR) in Nurul Fikri Islamic School as an approach to training students' thinking skills.
R. Rahmat, Dinn Wahyudin, Laksmi Dewi
doaj +1 more source
課程本位閱讀測量之研究現況與發展趨勢 Review and Analysis of Research on Curriculum-based Reading Measurement
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan, 2014 課程本位測量是監控學生學習成長及評估教學效果的方法，能適時協助教師調整教學策略，進而提升學生學習成效，為瞭解課程本位測量在閱讀領域的研究現況與發展趨勢，特以國語文與英語文閱讀為範疇，進行課程本位測量理論與實務應用的探究。主要研究目的有四，其一，瞭解課程本位測量之意義、內容與特色；其二，暸 解課程本位閱讀測量之研究現況及研究工具發展的情形；其三，瞭解國語文及英語文課程本位閱讀測量的相關研究；其四，針對課程本位閱讀測量未來研究方向及實務應用，提出若干建議。 Curriculum-based ...
吳玉珍 Yuh-Jen Wu +1 more
doaj +1 more source