Results 51 to 60 of about 314,573 (306)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploring the Effectiveness of Whatsapp Application on Teaching and Learning at One Midlands Teacher Education Institution in Zimbabwe [PDF]

E-Journal of Humanities, Arts and Social Sciences
Generally, social media platforms have been utilised to convey personal and non-academic information. Lecturers at higher education institutions have treated social media as a non-formal means of communication.
Shoorai Konyana, Motalenyane Alfred Modise   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Investigating the role of virtual tests in reducing stress from the perspective of faculty members and students of Payame Noor University [PDF]

Fanāvarī-i āmūzish, 2019
Background and Objective:Test anxiety is one of the state stresses that is closely related to the performance and academic achievement of millions of students in educational centers.
Sh. Ranjdoust
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evaluation of Units Established for Curriculum Support: A Collaborative Action Research

International Journal of Contemporary Educational Research
The curriculum includes educational activities that determine the struggle for survival and sustainability of a university's departments. Approaches that seek more flexible solutions and have a post-positivist understanding are needed to manage this ...
Şükran Tok, Sevda Dolapcıoglu, Kudret Öztürk   +2 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Integration of visible thinking routine in Nurul Fikri Islamic School as an effort to train thinking skills

Research and Development in Education
This study aimed to analyze the implementation of the Visible Thinking Routine (VTR) in Nurul Fikri Islamic School as an approach to training students' thinking skills.
R. Rahmat, Dinn Wahyudin, Laksmi Dewi
doaj   +1 more source

課程本位閱讀測量之研究現況與發展趨勢 Review and Analysis of Research on Curriculum-based Reading Measurement

Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan, 2014
課程本位測量是監控學生學習成長及評估教學效果的方法，能適時協助教師調整教學策略，進而提升學生學習成效，為瞭解課程本位測量在閱讀領域的研究現況與發展趨勢，特以國語文與英語文閱讀為範疇，進行課程本位測量理論與實務應用的探究。主要研究目的有四，其一，瞭解課程本位測量之意義、內容與特色；其二，暸 解課程本位閱讀測量之研究現況及研究工具發展的情形；其三，瞭解國語文及英語文課程本位閱讀測量的相關研究；其四，針對課程本位閱讀測量未來研究方向及實務應用，提出若干建議。 Curriculum-based ...
吳玉珍 Yuh-Jen Wu , 劉佩雲 Pei-Yun Liu   +1 more
doaj   +1 more source