Results 101 to 110 of about 350,893 (316)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Constant Scalar Curvature Metrics on Connected Sums
, 2001 The Yamabe problem (proved in 1984) guarantees the existence of a metric of constant scalar curvature in each conformal class of Riemannian metrics on a compact manifold of dimension $n \geq 3$, which minimizes the total scalar curvature of this ...
Joyce, D, Dominic Joyce, Joyce, Dominic
core +2 more sources
SSRN Electronic Journal, 2021 In a Mirrleesian environment, a monopsonist sets hourly wages and individuals choose how many hours to work. Labor market outcomes do not only depend on the level and slope of the income tax function, but also on its curvature. A more concave tax schedule raises the elasticity of labor supply, which boosts wages.
openaire +7 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Infraspecific Variation in Silene Seed Tubercles
PlantsThe seeds of many species in the order Caryophyllales exhibit surface protuberances called tubercles. While tubercle shape and distribution have often been proposed as taxonomic criteria, paradoxically, their description has primarily relied on ...
José Javier Martín-Gómez +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A comprehensive analysis of long bone curvature in Neanderthals and modern humans using 3D morphometrics [PDF]
, 2008 Since their discovery Neanderthals were described as having a marked degree of anteroposterior curvature of the femoral shaft. Although initially believed to be pathological, subsequent discoveries of Neanderthal remains made femoral curvature as well as
De Groote, Isabelle, de Groote, I.E.P.M.
core
Identification of Local Lubrication Regimes on Textured Surfaces by 3D Roughness Curvature Radius
, 2014 This paper proposes a new method of 3D roughness peaks curvature radius calculation and its application to tribological contact analysis as a characteristic signature of tribological contact.
Bigerelle, M. +15 more
core +1 more source
Exploiting non-parallel risk premia in the South African sovereign bond market
South African Journal of Economic and Management SciencesBackground: This study focuses on diversifying fixed income attribution beyond yield and duration by identifying new risk premia applicable to various investment strategies.
Sanveer Hariparsad, Eben Maré
doaj +1 more source
Sensory prediction on a whiskered robot: A tactile analogy to "optic flow"
Frontiers in Neurorobotics, 2012 When an animal moves an array of sensors (e.g., the hand, the eye) through the environment, spatial and temporal gradients of sensory data are related by the velocity of the moving sensory array.
Christopher L Schroeder +2 more
doaj +1 more source