Results 91 to 100 of about 103,223 (251)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Covering gonality of symmetric products of curves and Cayley–Bacharach condition on Grassmannians
Forum of Mathematics, SigmaGiven an irreducible projective variety X, the covering gonality of X is the least gonality of an irreducible curve $E\subset X$ passing through a general point of X. In this paper, we study the covering gonality of the k-fold symmetric product
Francesco Bastianelli, Nicola Picoco
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Mechanism and test analysis of rail corrugation
Journal of Advanced Mechanical Design, Systems, and ManufacturingIn view of the common phenomenon of rail corrugation on subway lines, both field measurement and numerical simulation were used to study mechanism of rail corrugation. In field measurement, vibration signals of vehicles were measured when a train passing
Dilai CHEN +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Research on adaptability in horizontal curve negotiation of HTS maglev train
机车电传动To enhance the curve negotiation performance of high-temperature superconducting (HTS) maglev trains equipped with a rigid levitation frame, this paper proposes a semi-decoupled levitation frame structure with specific degrees of freedom in both pitching
LI Qiang +4 more
doaj
Deformation Effect Analysis of Shield Tunnel Closely Side-passing Viaduct Pile Foundation
Chengshi guidao jiaotong yanjiuObjective Shield tunneling may cause displacement and deformation of the nearby viaduct foundation and reduce its bearing capacity. Therefore, the deformation effect caused by shield tunnel closely side-passing viaduct foundation is studied based on an ...
MA Fenghai, WANG Qi, YAN Pan
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source