Results 61 to 70 of about 103,223 (251)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A Novel Condition to the Harmonic of the Velocity Vector Field of a Curve in Rn

Discrete Dynamics in Nature and Society, 2017
In this paper, a condition is obtained for the harmonic of the velocity vector field in the curve family passing through the fixed p and q points in Rn. It shows that the condition can be expressed in terms of the curvature functions. Finally, we give an
Ayşe Altın, Canan Köroğlu
doaj   +1 more source

Geometry of curves passing through Whitney umbrella

We study geometry of curves passing through a Whitney umbrella by using a Darboux frame along it. We define three invariants by using Frenet-Serre type formula relating to the geodesic curvature, the normal curvature, and the geodesic torsion. We investigate the degrees of divergence and the top-terms of these invariants and their geometric meanings ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Analysis of a tram car ride when passing point frog and when entering curve by specific rail geometry

MATEC Web of Conferences, 2019
In urban railway environments, the problem of tramcars passing small radius arches appears to be topical. In this regard, the authors proposed that the wheelsets should be complemented on the outer side of the wheels with a second tread of a lower radius,
Hauser Vladimír, Gerlici Juraj, Kravchenko Kateryna, Lack Tomáš, Loulová Mária   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Calculation Method of Tram Car with 5 Module and Low Floor Passing through Curve

机车电传动, 2017
In this paper, the calculation of the suspended-modular-tram car with 5 module and low floor passing through curves was designed to study important parameters such as the rotation angle of the articulated equipment and the rotation angle of the coupler ...
NIE Min, CUI Qichao, YUAN Zhiqiang, WANG Yu   +3 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Predictive validity evidence of Yes-No Angoff standard setting in a Pre-Clinical medical school curriculum

BMC Medical Education
Background Standard setting plays a critical role in determining student outcomes by defining the level of biomedical knowledge required to be considered competent. This is especially important for accurately classifying medical students as ready (or not)
Ketsia Dimanche, Edward C. Klatt, S. Marshall Angle Jr.   +2 more
doaj   +1 more source