Results 91 to 100 of about 320,713 (303)
Fitting the Curve: Linear Sprint Modelling in Team Sports
, 2023 Daniel Geneau +5 more
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Accelerated Curve Fitting Approach for Denoised NQR Signal Parameter Estimation
ElectronicsSignal parameters such as amplitude, frequency, decay constant, and phase play an important role in identifying the signal’s origin in many real-life applications.
K. Thulasiram Varma, Rangababu Peesapati
doaj +1 more source
Curve Fitting with Clothoidal Splines
Journal of Research of the National Bureau of Standards, 1982 Clothoids, i.e. curves Z(s) in R 2 whose curvatures x(s) are linear fitting functions of arclength s, have been used for some time for curve fitting purposes in engineering applications. The first part of the paper deals with some basic interpolation problems for clothoids and studies the existence and uniqueness of their solutions.
openaire +3 more sources
Fitting and testing for the implied volatility curve using parametric models [PDF]
, 2011 Chuang‐Chang Chang +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Modeling Navigator Awareness of COLREGs Interpretation Using Probabilistic Curve Fitting
Journal of Marine Science and EngineeringDespite the existence of standardized collision regulations such as the International Regulations for Preventing Collisions at Sea (COLREGs), ship collisions continue to occur, indicating persistent gaps in how navigators interpret and apply these rules.
Deuk-Jin Park +4 more
doaj +1 more source
Detection of green apples in natural scenes based on saliency theory and Gaussian curve fitting
, 2018 Bairong Li, Yan Long, Huaibo Song
openalex +2 more sources