Results 111 to 120 of about 1,081,533 (280)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Modeling Navigator Awareness of COLREGs Interpretation Using Probabilistic Curve Fitting
Journal of Marine Science and EngineeringDespite the existence of standardized collision regulations such as the International Regulations for Preventing Collisions at Sea (COLREGs), ship collisions continue to occur, indicating persistent gaps in how navigators interpret and apply these rules.
Deuk-Jin Park +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Forecasting the Term Structure of Government Bond Yields [PDF]
Despite powerful advances in yield curve modeling in the last twenty years, comparatively little attention has been paid to the key practical problem of forecasting the yield curve. In this paper we do so.
Canlin Li, Francis X. Diebold
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Accelerated Curve Fitting Approach for Denoised NQR Signal Parameter Estimation
ElectronicsSignal parameters such as amplitude, frequency, decay constant, and phase play an important role in identifying the signal’s origin in many real-life applications.
K. Thulasiram Varma, Rangababu Peesapati
doaj +1 more source
Curve Fitting with Clothoidal Splines
Journal of Research of the National Bureau of Standards, 1982 Clothoids, i.e. curves Z(s) in R 2 whose curvatures x(s) are linear fitting functions of arclength s, have been used for some time for curve fitting purposes in engineering applications. The first part of the paper deals with some basic interpolation problems for clothoids and studies the existence and uniqueness of their solutions.
openaire +3 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source