Results 81 to 90 of about 103,222 (259)
BMC Medical EducationBackground Standard setting plays a critical role in determining student outcomes by defining the level of biomedical knowledge required to be considered competent. This is especially important for accurately classifying medical students as ready (or not)
Ketsia Dimanche +2 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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Chengshi guidao jiaotong yanjiuObjective In view of the high vehicle interior noise problem when running on curved lines, it is necessary to carry out in-depth research on its influencing factors.
FU Guoping +5 more
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Geometry of curves passing through Whitney umbrella
We study geometry of curves passing through a Whitney umbrella by using a Darboux frame along it. We define three invariants by using Frenet-Serre type formula relating to the geodesic curvature, the normal curvature, and the geodesic torsion. We investigate the degrees of divergence and the top-terms of these invariants and their geometric meanings ...
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Smooth curves on a cone which pass through its vertex
Manuscripta Mathematica, 1991 The author studies the existence of smooth curves passing through the vertex of the cone over a (possibly singular) plane curve \(D\) of degree \(d\). Given a positive integer \(m\), he gives conditions for there to exist such curves that meet each ruling of the cone \(m\) times. In particular, they exist if \(D\) is rational -- in this case, the proof
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Log-Cubic Method for Generation of Soil Particle Size Distribution Curve
The Scientific World Journal, 2013 Particle size distribution (PSD) is a fundamental physical property of soils. Traditionally, the PSD curve was generated by hand from limited data of particle size analysis, which is subjective and may lead to significant uncertainty in the freehand PSD ...
Songhao Shang
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