Results 71 to 80 of about 103,222 (259)

Study on Curve Passing Capacity of Independent Wheelset on Light Rail Vehicles

机车电传动, 2019
Aiming at the application of independent wheelset in light rail vehicles, a new structure of independent wheelset, which combined planetary differential and lower axle, was studied. The structure could improve the steering ability of independent wheelset.
Yongxiang WEN, Wenxiang ZHOU, Yang CHEN, Zhen ZHANG, Xiaoyang ZHANG   +4 more
doaj  

A Novel Condition to the Harmonic of the Velocity Vector Field of a Curve in Rn

Discrete Dynamics in Nature and Society, 2017
In this paper, a condition is obtained for the harmonic of the velocity vector field in the curve family passing through the fixed p and q points in Rn. It shows that the condition can be expressed in terms of the curvature functions. Finally, we give an
Ayşe Altın, Canan Köroğlu
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Analysis of a tram car ride when passing point frog and when entering curve by specific rail geometry

MATEC Web of Conferences, 2019
In urban railway environments, the problem of tramcars passing small radius arches appears to be topical. In this regard, the authors proposed that the wheelsets should be complemented on the outer side of the wheels with a second tread of a lower radius,
Hauser Vladimír, Gerlici Juraj, Kravchenko Kateryna, Lack Tomáš, Loulová Mária   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

ANALYSIS OF ACCELERATION OF CLASS E-8 RACE CAR EQUIPPED WITH VARIOUS TRANSMISSION OPTIONS [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2015
Analysis of dynamics of vehicle acceleration with three types of transmissions: with conventional mechanical, with duo flow without breaking the power flow and single flow without breaking the flow of power is presented.
М. Mikhalevych
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Calculation Method of Tram Car with 5 Module and Low Floor Passing through Curve

机车电传动, 2017
In this paper, the calculation of the suspended-modular-tram car with 5 module and low floor passing through curves was designed to study important parameters such as the rotation angle of the articulated equipment and the rotation angle of the coupler ...
NIE Min, CUI Qichao, YUAN Zhiqiang, WANG Yu   +3 more
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source