Results 61 to 70 of about 103,222 (259)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Impact of Shield Under-Passing on Existing Tunnel Settlement Considering Construction Factors

Chengshi guidao jiaotong yanjiu
[Objective] The construction of a new shield-tunneling tunnel under-passing the existing tunnel can induce the latter′s settlement and deformation. Therefore, it is necessary to study the impact of construction factors on the settlement of the existing ...
XUE Ziqian, XIA Hongchun, ZHU Xunguo, YAN Huajun   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Influence of Wheelset Structural Flexibility on High-speedEMUs Curve-passing Performance

机车电传动, 2013
In order to study the influence of the torsional mode, bending mode and umbrella mode of the wheelsets on the vehicle curvepassingperformance, the vehicle-track system dynamics models were established, in which, the wheelsets structures were considered ...
XU Chuan-lai, MI Cai-ying
doaj  

Rural Roads’ Passing Sight Distance Control Along Crest Vertical Curves

Infrastructures
Passing sight distance (PSD) is a vital design element that directly imposes economic, as well as safety and operational, considerations. The provision of PSD is highly prioritized, at least for rural road sections without additional passing lanes.
Stergios Mavromatis, Vassilios Matragos, Konstantinos Markos, Antonios Kontizas   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Design and research on a bogie model with articulated frame and inboard axle box for export to Los Angeles

机车电传动
In recent years, China has achieved rapid development in the fields of EMUs and metros, with original equipmentmanufacturers (OEMs) making significant strides in exploring foreign markets. CRRC Changchun Railway Vehicle Co., Ltd.
ZHANG Wenkang, XUE Shihai, LIU Haitao, ZHAO Zhuo, LIU Zhiyuan, GAO Chunyou   +5 more
doaj